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Libor Vítek and Martin Haluzík

insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats . Journal of Lipid Research 51 771 – 784 . ( doi:10.1194/jlr.M001602 ) Cotillard A Kennedy SP Kong LC Prifti E Pons N Le Chatelier

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Shaodong Guo

et al . (2012) Liver Foxo4 −/− Normal glucose levels Alb-cre Zhang et al . (2012) Liver Foxo1 −/− ∷ Foxo3 −/− ∷ Foxo4 −/ − Reduced blood glucose levels; increased triglyceride levels; hepatic steatosis Alb-cre Haeusler et al . (2010) and Zhang

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Patrice D Cani, Catherine A Daubioul, Brigitte Reusens, Claude Remacle, Grégory Catillon and Nathalie M Delzenne

.) ( Delzenne 2003 , Delzenne et al. 2003 ). We have shown in previous studies that oligofructose – a short chain fructan obtained from inulin -decreases steatosis by reducing spontaneous food intake in obese Zucker Fa/Fa rats ( Daubioul et al. 2002

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Greg M Kowalski, Michael J Kraakman, Shaun A Mason, Andrew J Murphy and Clinton R Bruce

:10.1152/ajpendo.90996.2008 ) Meex RC Hoy AJ Morris A Brown RD Lo JC Burke M Goode RJ Kingwell BA Kraakman MJ Febbraio MA 2015 Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose

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Zhongxiuzi Gao, Li Zhang, Wenting Xie, Siqi Wang, Xiaorui Bao, Yuli Guo, Houjian Zhang, Qingzhong Hu, Yi Chen, Zeen Wang, Maoqiang Xue and Guanghui Jin

53 1087 – 1097 . ( doi:10.1369/jhc.5C6684.2005 ) Cao Y Xue Y Xue L Jiang X Wang X Zhang Z Yang J Lu J Zhang C Wang W 2013 Hepatic menin recruits SIRT1 to control liver steatosis through histone

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Martina Bugáňová, Helena Pelantová, Martina Holubová, Blanka Šedivá, Lenka Maletínská, Blanka Železná, Jaroslav Kuneš, Petr Kačer, Marek Kuzma and Martin Haluzík

toxic insult, increased taurine synthesis and consequently taurine excretion into urine also. Obesity and insulin resistance are commonly associated with liver steatosis ( Fabbrini et al. 2010 ); therefore, the significant decrease in urine taurine

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Nailliw Z Preite, Bruna P P do Nascimento, Cynthia R Muller, Anna Laura V Américo, Talita S Higa, Fabiana S Evangelista, Carmen L Lancellotti, Felipe dos Santos Henriques, Miguel Luiz Batista Jr, Antonio C Bianco and Miriam O Ribeiro

feeding on a HFD resulted in a severe macrovesicular liver steatosis, with triglyceride accumulation in large hepatocyte vacuoles but similar in WT and ARβ 3 KO ( Fig. 5C , D and E ). HFD-induced glucose intolerance was similar in both groups ( Fig. 6

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I Sadaf Farooqi and Stephen O'Rahilly

et al . 1999 ). In those who survive, obesity continues in adult life, with hepatic steatosis ( von Schnurbein et al . 2013 ) and hyperinsulinaemia consistent with the severity of obesity. Some adults have developed type 2 diabetes in the third to

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Alia H Sukkar, Aaron M Lett, Gary Frost and Edward S Chambers

hepatic steatosis by dietary supplementation of SCFAs over a period of 12 weeks. One of the possible underlying mechanisms was the decrease in peroxisome proliferator-activated receptor gamma ( Pparg ) activity in the liver. Pparg increases energy

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Sun-O Ka, Mi-Young Song, Eun Ju Bae and Byung-Hyun Park

cytokines in the liver and adipose tissue and an increase in the number of CLSs. Notably, mS1KO mice on a HFD showed a decrease in hepatic triglycerides and steatosis and smaller adipocyte size compared with WT mice. These findings are in contrast to those