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Akiko Mizokami, Satoru Mukai, Jing Gao, Tomoyo Kawakubo-Yasukochi, Takahito Otani, Hiroshi Takeuchi, Eijiro Jimi and Masato Hirata

diabetic condition by affecting multiple aspects of systemic glucose and energy metabolism ( Lee et al. 2007 a , Ferron et al. 2008 , 2010 , Fulzele et al. 2010 ) in a manner dependent on interaction with its putative receptor GPRC6A ( Oury et

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Yusuke Taguchi, Yoshie Tasaki, Kiyoshi Terakado, Kenichi Kobayashi, Takeo Machida and Tetsuya Kobayashi

reduced by an excess of thyroid hormones ( Lenzen & Bailey 1984 ). On the other hand, hypothyroidism is associated with deterioration of glucose metabolism, and this effect is accompanied by reduced plasma insulin concentrations but increased plasma

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Li Ding, Yue Yin, Lingling Han, Yin Li, Jing Zhao and Weizhen Zhang

the age of neonate, weaning and 16 weeks ( Fig. 3I ). Alteration in glucose tolerance and insulin sensitivity in Ngn3-Tsc1−/− mice As insulin is crucial for glucose metabolism, we next examined the fasting blood glucose levels, oral glucose

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Hasan Kulaksiz, Evelyn Fein, Peter Redecker, Wolfgang Stremmel, Guido Adler and Yalcin Cetin

, Pietrangelo 2004 , Beutler 2006 ) and the association of hepcidin mutations with severe juvenile hemochromatosis ( Roetto et al . 2003 ). It has been repeatedly reported that iron influences glucose metabolism, which in turn affects iron metabolic pathways

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Jonathan M Mudry, Julie Massart, Ferenc L M Szekeres and Anna Krook

hypothesized that TWIST proteins may be involved in skeletal muscle glucose and lipid metabolism, as well as in the regulation of expression of skeletal muscle-derived cytokines. Materials and methods Human subjects Male and female volunteers with type 2

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Vanesa Jiménez-Amilburu, Susanne Jong-Raadsen, Jeroen Bakkers, Herman P Spaink and Rubén Marín-Juez

indicate that further in-depth studies on the physiological role of GLUT12 will make important contributions to better understand the connection between heart failure and pathologies impacting the glucose metabolism. In this work, we used zebrafish ( Danio

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Camilla Alexanderson, Elias Eriksson, Elisabet Stener-Victorin, Malin Lönn and Agneta Holmäng

metabolism, for example, by altering muscle glucose transport ( Ozanne et al . 1996 , Perello et al . 2003 , Vaag et al . 2006 , Muhlhausler et al . 2007 , Vickers 2007 , Boullu-Ciocca et al . 2008 , Shankar et al . 2008 ). One group of molecules

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Che-Pei Kung and Maureen E Murphy

Ruppin E Rotter V 2013 p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production . Cancer & Metabolism 1 9 . ( doi:10.1186/2049-3002-1-9 ) Grant SF Thorleifsson G Reynisdottir I

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Meng Guo, Yuna Li, Yan Wang, Zhenkun Li, Xiaohong Li, Peikun Zhao, Changlong Li, Jianyi Lv, Xin Liu, Xiaoyan Du and Zhenwen Chen

expression by up-regulating ATF4. In conclusion, we demonstrated that eEF1A2 impaired insulin sensitivity in male insulin-resistant skeletal muscle via PKCβ activation and ER stress. Our study identifies the role of eEF1A2 in glucose metabolism in animals

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Claudia E Robert-Cooperman, Grace C Dougan, Shari L Moak, Mark G Athanason, Melanie N Kuehl, Harris Bell-Temin, Stanley M Stevens Jr and Brant R Burkhardt

. ( doi:10.1146/annurev.biochem.66.1.581 ) Jiang G Zhang BB 2003 Glucagon and regulation of glucose metabolism . American Journal of Physiology. Endocrinology and Metabolism 284 E671 – E678 . ( doi:10.1152/ajpendo.00492.2002 ) Johansson P