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Maria Carolina S Mendes, Gustavo D Pimentel, Felipe O Costa and José B C Carvalheira

immune system in response to tissue stress or infection serves as an adaptive response that is essential to host survival ( Ramos et al . 2004 ). These responses include fever, headache, changes in the sleep–wake cycle, anorexia, fatigue, and nausea

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Local control of thyroid hormone action: role of type 2 deiodinase

Deiodinases: the balance of thyroid hormone

Graham R Williams and J H Duncan Bassett

breadth of expression of DIO2 and its response to cellular stress ( Gereben et al . 2008 ), it is likely that the functional repertoire for DIO2 will expand. The immediate challenges will be to identify these new roles and to determine whether functions

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K A Walters, V Rodriguez Paris, A Aflatounian and D J Handelsman

endocrine, reproductive, metabolic and psychological features. Polycystic ovaries classically exhibit aberrant follicle maturation which leads to ovulatory dysfunction and is associated with reduced fertility ( Dumesic et al. 2015 ). If pregnancy is