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Hyunju Chung, Sanghee Seo, Minho Moon, and Seungjoon Park

survival is associated with its ability to prevent the apoptosis induced by various insults. Several evidences suggest that endogenous IGF-I plays a significant role in recovery from insults such as hypoxia–ischemia ( Komoly et al. 1992 , Beilharz et al

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Morag J Young, Colin D Clyne, and Karen E Chapman

unusual degree of hypoxia observed ( Sardu et al. 2020 ). Indeed, one of the remarkable features of COVID-19 is its association with an unusually low degree of blood oxygenation in the absence of other symptoms (such as problems breathing), associated

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Pi-Jung Hsiao, Ming-Ying Lu, Feng-Yu Chiang, Shyi-Jang Shin, Yu-Da Tai, and Suh-Hang Hank Juo

. 1999 , Stewart et al. 2001 , Woodward et al. 2005 ). Androgens can activate hypoxia inducible factor-1 ( Mabjeesh et al. 2003 ) which in turn translocates into nucleus to enhance VEGF expression ( Josko & Mazurek 2004 ). On the other hand

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Paolo Comeglio, Ilaria Cellai, Tommaso Mello, Sandra Filippi, Elena Maneschi, Francesca Corcetto, Chiara Corno, Erica Sarchielli, Annamaria Morelli, Elena Rapizzi, Daniele Bani, Daniele Guasti, Gabriella Barbara Vannelli, Andrea Galli, Luciano Adorini, Mario Maggi, and Linda Vignozzi

transaminases (AST and ALT) analyses were obtained from the marginal ear vein at week 12, in all groups. Histomorphometric analysis and hypoxia detection in VAT Immunohistochemical localization of FXR and TGR5 was performed on deparaffinized rehydrated

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Trassanee Chatmethakul and Robert D Roghair

2014 , Taylor et al. 2014 ). Potential triggers of the pathologic cascade include reduced caloric intake, nutritional imbalance and hypoxia, all of which affect the growth and maturation of organ systems and influence homeostatic regulation. The

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Eun Hee Koh, Ah-Ram Kim, Hyunshik Kim, Jin Hee Kim, Hye-Sun Park, Myoung Seok Ko, Mi-Ok Kim, Hyuk-Joong Kim, Bum Joong Kim, Hyun Ju Yoo, Su Jung Kim, Jin Sun Oh, Chang-Yun Woo, Jung Eun Jang, Jaechan Leem, Myung Hwan Cho, and Ki-Up Lee

include adipose tissue hypoxia ( Ye et al . 2007 , Jiang et al . 2011 ), increased proinflammatory cytokine levels, and oxidative stress in dysfunctional adipocytes ( Otani 2011 ). Another hypothesis that links adipocyte hypertrophy to reduced

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Hyo Youl Moon, Parkyong Song, Cheol Soo Choi, Sung Ho Ryu, and Pann-Ghill Suh

28 339 – 350 . ( doi:10.1055/s-0028-1091978 ) Lee M Hwang JT Lee HJ Jung SN Kang I Chi SG Kim SS Ha J 2003 AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target

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N Grion, E M Repetto, Y Pomeraniec, C Martinez Calejman, F Astort, R Sanchez, O P Pignataro, P Arias, and C B Cymeryng

expression is induced by a multiplicity of effectors like endotoxin, interferon (IFN)-γ, tumor necrosis factor-α, hypoxia, stress, and tissue damage ( Michel & Feron 1997 ). In mammals, microsomal heme oxygenase (HO) is the rate-controlling enzyme for

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Hasan Kulaksiz, Evelyn Fein, Peter Redecker, Wolfgang Stremmel, Guido Adler, and Yalcin Cetin

Introduction Iron is an essential component of hemoglobin and myoglobin and of many enzymes involved in redox reactions and energy metabolism. Low levels of iron in the circulation may cause severe dysfunctions (e.g., anemia, hypoxia) while iron

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Hyo-Sup Kim, Seung-Hyun Hong, Seung-Hoon Oh, Jae-Hyeon Kim, Myung-Shik Lee, and Moon-Kyu Lee

blood glucose measurements (data not shown). Differentiated ductal cells (1×10 6 ) infected with 1×10 8 pfu adenovirus-GFP were transplanted into the subcapsular spaces of the left kidneys of each group of mice. To determine whether hypoxia was induced