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Deborah M Sloboda, Timothy J M Moss, Shaofu Li, Stephen G Matthews, John R G Challis and John P Newnham

effects of maternal betamethasone injection on fetal development throughout gestation and early neonatal life; and Cohort 2, a cohort designed to evaluate long-term effects of prenatal maternal or fetal betamethasone injections on adult sheep offspring

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Anna H Kongsted, Sanne V Husted, Malin P Thygesen, Vibeke G Christensen, Dominique Blache, Anders Tolver, Torben Larsen, Bjørn Quistorff and Mette O Nielsen

and humans have similar developmental patterns in the last trimester: their offspring are born physiologically precocial, which means that they are much more mature at birth than rodent and porcine offspring, which are born altricial. We have reported

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Astrid Chamson-Reig, Edith J Arany, Kelly Summers and David J Hill

calorie restriction of the pregnant NOD mouse delayed the onset of diabetes in the female offspring and reduced insulitis at 12 weeks of age ( Oge et al . 2007 ). A human correlate would be the lower incidence of type 1 diabetes seen in individuals born

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P Nguyen, S Khurana, H Peltsch, J Grandbois, J Eibl, J Crispo, D Ansell and T C Tai

in male offspring of Wistar-Kyoto (WKY) dams injected with dexamethasone (DEX). Results from this study show changes in key transcription factors regulating PNMT expression in the adrenal glands of DEX-treated male WKY offspring, coincident with

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María Florencia Heber, Silvana Rocío Ferreira, Giselle Adriana Abruzzese, Raíces Trinidad, Omar P Pignataro, Margarita Vega and Alicia B Motta

programming by prenatal hyperandrogenization which leads to PCOS features in female offspring ( Heber et al. 2013 , Abruzzese et al. 2016 ), and, among other characteristics, presents an insulin resistance state since puberty ( Abruzzese et al. 2016

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Cun Li, Thomas J McDonald, Guoyao Wu, Mark J Nijland and Peter W Nathanielsz

( Schlabritz-Loutsevitch et al . 2007 ). Fetal cortisol is also elevated ( Nijland et al . 2010 ) and offspring show an altered postnatal phenotype with decreased peripheral glucose disposal and elevated fasting glucose ( Choi et al . 2011 ) and behavior

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Valentina Pampanini, Daniela Germani, Antonella Puglianiello, Jan-Bernd Stukenborg, Ahmed Reda, Iuliia Savchuk, Kristín Rós Kjartansdóttir, Stefano Cianfarani and Olle Söder

assigned to feeding dams. To standardize postnatal conditions (i.e. to ensure an equal access to lactation) litter sizes were reduced to six offspring. Pup weights were recorded on day 0 and subsequently once a week until the end of experiments. At 21 days

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Ariadni Spyroglou, Sibylle Sabrautzki, Birgit Rathkolb, Tarik Bozoglu, Martin Hrabé de Angelis, Martin Reincke, Martin Bidlingmaier and Felix Beuschlein

offspring derived from their mating. For details and nomenclature, refer to Table 1 . Table 1 Nomenclature for C3HeB/FeJ and C57BL/6J mice and their F1 and F2 offspring Generation Paternal×maternal origin Abbreviation F0 C3HeB/FeJ CCCC C57BL/6J BBBB F1 C57

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P W F Hadoke, R S Lindsay, J R Seckl, B R Walker and C J Kenyon

glucose tolerance and elevated blood pressure in adult offspring ( Benediktsson et al. 1993 , Lindsay et al. 1996 , Dodic et al. 1998 ). The mechanisms by which prenatal programming induces adult hypertension have not been established. One

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Kazunari Nohara, Suhuan Liu, Matthew S Meyers, Aurélie Waget, Mathieu Ferron, Gérard Karsenty, Rémy Burcelin and Franck Mauvais-Jarvis

reproductive and metabolic abnormalities of the offspring ( Abbott et al . 2005 , Xita & Tsatsoulis 2006 , 2010 ). Female primates and rodents exposed to androgen excess during critical periods of perinatal development go on to exhibit a predominantly