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F Sentinelli, E Filippi, M G Cavallo, S Romeo, M Fanelli and M G Baroni

(TZDs), are a class of antidiabetic agents that act by improving insulin sensitivity ( Nolan et al. 1994 , Zierath et al. 1998 ). TZDs exert their antidiabetic actions by various mechanisms: enhancing insulin signaling, increasing glucose

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Sian J S Simpson, Lorna I F Smith, Peter M Jones and James E Bowe

respond to exogenous insulin administration and lowering of blood glucose; however, none of the CRHR antagonists had any detectable effects on insulin sensitivity ( Fig. 4C and D ). Chronic treatment of non-pregnant female mice with α-helical CRF 9

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L A Santiago, D A Santiago, L C Faustino, A Cordeiro, P C Lisboa, F E Wondisford, C C Pazos-Moura and T M Ortiga-Carvalho

serum levels of insulin ( Fig. 4 B, P <0.05). The HOMA-IR, calculated as the product between serum insulin and blood glucose, was 60% lower in mice carrying the mutation, suggesting that their insulin sensitivity was increased ( Fig. 4 C, P <0

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Rebecca L Hull, Joshua R Willard, Matthias D Struck, Breanne M Barrow, Gurkirat S Brar, Sofianos Andrikopoulos and Sakeneh Zraika

were determined using the Mouse Ultrasensitive Insulin ELISA (Alpco, Salem, NH, USA). Data and statistical analyses Data are presented as mean ±  s.e.m. for the number of mice or experiments indicated. Insulin sensitivity was expressed as the

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Beatriz S Amorim, Cintia B Ueta, Beatriz C G Freitas, Renata J Nassif, Cecília Helena de Azevedo Gouveia, Marcelo A Christoffolete, Anselmo S Moriscot, Carmen Lucia Lancelloti, Flávia Llimona, Hermes Vieira Barbeiro, Heraldo Possolo de Souza, Sergio Catanozi, Marisa Passarelli, Marcelo S Aoki, Antonio C Bianco and Miriam O Ribeiro

). Whereas the GC-24-treated animals still had significant fasting hyperglycemia (96.5 mg/dl), the maximum 30-min glucose peak was ∼30% reduced ( Fig. 2 A). Insulin sensitivity was increased at early time points after insulin administration in GC-24-treated

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Milos Lazic, Fraser Aird, Jon E Levine and Andrea Dunaif

, n =17; T, n =14; D, n =19. Dynamic testing Following IPGTT, there were no differences in glucose or insulin responses among T, D, and C males ( Fig. 4 ). There were no differences in insulin sensitivity assessed by IPITT among T, D, and C males

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Sofianos Andrikopoulos, Barbara C Fam, Anita Holdsworth, Sherley Visinoni, Zheng Ruan, Maria Stathopoulos, Anne W Thorburn, Christos N Joannides, Michael Cancilla, Lois Balmer, Joseph Proietto and Grant Morahan

tolbutamide stimulation. Taken together, these data suggest that Abcc8/Kcnj11 is partly responsible for the defect in early-phase glucose-mediated insulin secretion in the NZO mouse. Glucose tolerance and insulin sensitivity in NZO transgenic mice Since

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Amy Warner and Jens Mittag

, therefore increasing insulin sensitivity. Recent studies have shown that by increasing the volume of BAT through cold exposure, glucose clearance also improves ( van der Lans et al . 2013 , Chondronikola et al . 2014 ). However, this requires constant

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Victor A Gault, David W Porter, Nigel Irwin and Peter R Flatt

.p. glucose tolerance (18 mmol/kg body weight) test and insulin sensitivity (10 U/kg body weight) test were similarly performed at 1000 h in freely fed mice. The i.p. route was chosen as the method of glucose delivery, as this will bypass the stomach and

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Jin-Bong Lee, Sung-Jin Yoon, Sang-Hyun Lee, Moo-Seung Lee, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon, Inpyo Choi, Ik-Soo Kim, Su Wol Chung, Hee Gu Lee, Jeong-Ki Min and Young-Jun Park

adipose tissue expansion is considered beneficial and is marked by improved insulin sensitivity, reduced angiogenesis, reduced dysfunctional adipocyte hypertrophy and increases in fibrosis, hypoxia and the infiltration of M1 adipose tissue macrophages and