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Folami Y Ideraabdullah, Anthony M Belenchia, Cheryl S Rosenfeld, Seth W Kullman, Megan Knuth, Debabrata Mahapatra, Michael Bereman, Edward D Levin and Catherine A Peterson

generation offspring of VDD dams displayed greater body and epididymal fat mass ( Nascimento et al. 2013 ). These mice also had increased insulin secretion when given an oral glucose challenge and showed marked hepatic steatosis. An in utero VDD Sprague

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Haijiang Wu, Xinna Deng, Yonghong Shi, Ye Su, Jinying Wei and Huijun Duan

inhibitor ameliorates hepatic steatosis by improving ER stress and inflammation in a type 2 diabetic mouse model . PLoS ONE 10 e0120711 . ( doi:10.1371/journal.pone.0120711 ) Knutti D Kaul A Kralli A 2000 A tissue-specific coactivator of

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Jarrad M Scarlett, Darren D Bowe, Xinxia Zhu, Ayesha K Batra, Wilmon F Grant and Daniel L Marks

pronounced liver steatosis, we did not observe liver steatosis in the Band-AGRP rats. In summary, our data suggest that the central melanocortin system, a neural integrator of hormone and cytokine signaling that regulates feeding behavior, linear growth, and

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A Feraco, A Armani, R Urbanet, A Nguyen Dinh Cat, V Marzolla, F Jaisser and M Caprio

2010 Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet . Endocrinology 151 2040 – 2049 . ( https

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Liselotte Fransson, Stephanie Franzén, Victoria Rosengren, Petra Wolbert, Åke Sjöholm and Henrik Ortsäter

P <0.05 was considered statistically significant. Results Corticosterone exposure induces obesity, dyslipidemia, ectopic steatosis, and hypertension Mice receiving corticosterone via their drinking water developed enlarged fat deposits ( Fig. 1 A and

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Juliana Gastão Franco, Egberto Gaspar de Moura, Josely Correa Koury, Paula Affonso Trotta, Aline Cordeiro, Luana Lopes Souza, Norma Aparecida dos Santos Almeida, Natália da Silva Lima, Carmen Cabanelas Pazos-Moura, Patrícia Cristina Lisboa and Magna Cottini Fonseca Passos

addition, moderate overexpression of SIRT1 protected cells from oxidative stress ( Csiszar et al . 2006 , Alcendor et al . 2007 , Lee et al . 2009 ), and hepatic SIRT1 action attenuated hepatic steatosis, inflammation, and oxidative stress

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Aline Cordeiro, Luana Lopes de Souza, Lorraine Soares Oliveira, Larissa Costa Faustino, Letícia Aragão Santiago, Flavia Fonseca Bloise, Tania Maria Ortiga-Carvalho, Norma Aparecida dos Santos Almeida and Carmen Cabanelas Pazos-Moura

persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity . Journal of Biological Chemistry 286 22227 – 22234 . ( doi:10.1074/jbc.M111.228874 ) Guigon CJ Zhao L Lu C Willingham MC Cheng SY 2008

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Takuro Okamura, Yoshitaka Hashimoto, Takafumi Osaka, Takafumi Senmaru, Takuya Fukuda, Masahide Hamaguchi and Michiaki Fukui

. Journal of Diabetes Investigation 242 – 246 . ( https://doi.org/10.1111/jdi.12319 ) Hashimoto Y Osaka T Fukuda T Tanaka M Yamazaki M Fukui M 2016 The relationship between hepatic steatosis and skeletal muscle mass index in men with type

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Hong Ma, Jin Yuan, Jinyu Ma, Jie Ding, Weiwei Lin, Xinlei Wang, Mingliang Zhang, Yi Sun, Runze Wu, Chun Liu, Cheng Sun and Yunjuan Gu

has shown that deficiency of JNK1 in hepatocytes exhibits glucose intolerance, insulin resistance and hepatic steatosis ( Sabio et al. 2009 ). One explanation is that the kinase activity of JNK2 may be stimulated in the Jnk1 −/− liver, although the

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Zhengu Liu, Violeta Stanojevic, Luke J Brindamour and Joel F Habener

insulin resistance. This circumstance manifests in hyperglycemia, hyperlipidemia, hypertension, atherosclerosis, and steatosis of major organs such as the liver (nonalcoholic fatty liver disease), heart (lipotoxic cardiomyopathy), brain (Alzheimer