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Alia H Sukkar, Aaron M Lett, Gary Frost, and Edward S Chambers

hepatic steatosis by dietary supplementation of SCFAs over a period of 12 weeks. One of the possible underlying mechanisms was the decrease in peroxisome proliferator-activated receptor gamma ( Pparg ) activity in the liver. Pparg increases energy

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M K Piya, P G McTernan, and S Kumar

. ↑ Preadipocyte cell proliferation, as with TNFα Sporn et al . (1987) and Fain et al . (2005) MCP1 Increases insulin resistance, macrophage infiltration in adipose tissue and hepatic steatosis Secreted by WAT ↑ ob/ob and db/db mice. ↑ In obesity, T2DM and

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Milos Mraz and Martin Haluzik

migration ( Gerhardt et al . 2001 , Christiansen et al . 2005 ). Overexpression of MCP1 leads to ATM infiltration, IR, and liver steatosis without increasing body weight, while deletion of MCP1 or macrophage CCR2 reduces ATM numbers in AT and improves

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Haijiang Wu, Xinna Deng, Yonghong Shi, Ye Su, Jinying Wei, and Huijun Duan

inhibitor ameliorates hepatic steatosis by improving ER stress and inflammation in a type 2 diabetic mouse model . PLoS ONE 10 e0120711 . ( doi:10.1371/journal.pone.0120711 ) Knutti D Kaul A Kralli A 2000 A tissue-specific coactivator of

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Folami Y Ideraabdullah, Anthony M Belenchia, Cheryl S Rosenfeld, Seth W Kullman, Megan Knuth, Debabrata Mahapatra, Michael Bereman, Edward D Levin, and Catherine A Peterson

generation offspring of VDD dams displayed greater body and epididymal fat mass ( Nascimento et al. 2013 ). These mice also had increased insulin secretion when given an oral glucose challenge and showed marked hepatic steatosis. An in utero VDD Sprague

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Ya Pei, Honggui Li, Yuli Cai, Jing Zhou, Xianjun Luo, Linqiang Ma, Kelly McDaniel, Tianshu Zeng, Yanming Chen, Xiaoxian Qian, Yuqing Huo, Shannon Glaser, Fanyin Meng, Gianfranco Alpini, Lulu Chen, and Chaodong Wu

Mashek DG , 2012 Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice . PLoS ONE 7 e39286 . ( ) 10.1371/journal.pone.0039286 22768070 Guo X Li H Xu H Halim V

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Rosalba Senese, Federica Cioffi, Pieter de Lange, Fernando Goglia, and Antonia Lanni

/kg BW) acutely. After 6 h, a significant increase in RMR was detected in both patients. Daily T 2 administration for 28 days increased RMR by ∼15% and decreased BW by about 4 kg. Ultrasonography revealed that one subject showed reductions in steatosis

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Juliana Gastão Franco, Egberto Gaspar de Moura, Josely Correa Koury, Paula Affonso Trotta, Aline Cordeiro, Luana Lopes Souza, Norma Aparecida dos Santos Almeida, Natália da Silva Lima, Carmen Cabanelas Pazos-Moura, Patrícia Cristina Lisboa, and Magna Cottini Fonseca Passos

addition, moderate overexpression of SIRT1 protected cells from oxidative stress ( Csiszar et al . 2006 , Alcendor et al . 2007 , Lee et al . 2009 ), and hepatic SIRT1 action attenuated hepatic steatosis, inflammation, and oxidative stress

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Daniela Álvarez, Karina Ceballo, Sofía Olguín, Jonathan Martinez-Pinto, Manuel Maliqueo, Daniela Fernandois, Ramón Sotomayor-Zárate, and Gonzalo Cruz

Introduction Maternal obesity is associated with various endocrine and metabolic disorders in offspring, including obesity ( Paliy et al. 2014 ), hepatic steatosis ( Oben et al. 2010 , Mouralidarane et al. 2013 ), diabetes mellitus

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Aline Cordeiro, Luana Lopes de Souza, Lorraine Soares Oliveira, Larissa Costa Faustino, Letícia Aragão Santiago, Flavia Fonseca Bloise, Tania Maria Ortiga-Carvalho, Norma Aparecida dos Santos Almeida, and Carmen Cabanelas Pazos-Moura

persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity . Journal of Biological Chemistry 286 22227 – 22234 . ( doi:10.1074/jbc.M111.228874 ) Guigon CJ Zhao L Lu C Willingham MC Cheng SY 2008