Search Results

You are looking at 101 - 110 of 619 items for :

  • Acute insulin resistance x
Clear All
Free access

Sojin Lee and H Henry Dong

insulin-resistant condition, hepatic acetyl-CoA levels become higher, fueling hepatic gluconeogenesis. This effect is acutely inhibited by insulin. Insulin suppresses lipolysis in adipose tissues to limit hepatic acetyl-CoA levels, contributing to the

Free access

Zhongxiuzi Gao, Li Zhang, Wenting Xie, Siqi Wang, Xiaorui Bao, Yuli Guo, Houjian Zhang, Qingzhong Hu, Yi Chen, Zeen Wang, Maoqiang Xue and Guanghui Jin

resulted in impairment of glucose metabolism in 12-month-old male mice; however, it did not induce insulin resistance. Instead, it promoted glucagon production and increased hepatic glucose output (HGO), which together contributed to increased glucose

Free access

Guoyue Yuan, Xia Chen, Qinyun Ma, Jie Qiao, Rongying Li, Xuesong Li, Shengxian Li, Jinfeng Tang, Libin Zhou, Huaidong Song and Mingdao Chen

. Festa A , D’Agostino R, Jr, Tracy RP & Haffner SM 2002 Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes 51 1131

Free access

Véronique Serre-Beinier, Christian Toso, Philippe Morel, Carmen Gonelle-Gispert, Christelle Veyrat-Durebex, Françoise Rohner-Jeanrenaud, Thierry Calandra, Thierry Roger, Richard W James, Xavier Montet, Léo Bühler, Domenico Bosco and Thierry Berney

were performed in the setting of stress, several reports have also documented an association between MIF, obesity, and insulin resistance (IR) in a physiological environment. MIF secretion and serum concentration are increased in obese individuals or in

Free access

Mathis Grossmann

the effects of testosterone on insulin resistance occur via changes in body composition. There is also evidence that testosterone regulates insulin sensitivity directly and acutely ( Yialamas et al . 2007 ). Interestingly, a reciprocal feedback also

Free access

Rachel Botchlett, Shih-Lung Woo, Mengyang Liu, Ya Pei, Xin Guo, Honggui Li and Chaodong Wu

Introduction With the increasing prevalence of obesity worldwide, there is a drastic rise in the incidence of metabolic diseases. Metabolic syndrome, type 2 diabetes mellitus (T2DM)/insulin resistance, and cardiovascular disease are only a few

Free access

Louis Potier, Ludovic Waeckel, Fréderic Fumeron, Sophie Bodin, Marinos Fysekidis, Catherine Chollet, Naima Bellili, Fabrice Bonnet, Gaëlle Gusto, Gilberto Velho, Michel Marre, François Alhenc-Gelas, Ronan Roussel, Nadine Bouby and the DESIR study group

Introduction The prevalence of obesity is increasing worldwide, together with the metabolic and cardiovascular complications of the condition, related in part to insulin resistance ( Ogden et al . 2012 ). Intervention trials aimed at preventing

Restricted access

Zhengxiang Huang, Lili Huang, Chengjian Wang, Shanli Zhu, Xinzhou Qi, Yang Chen, Yanjun Zhang, Michael A Cowley, Johannes D Veldhuis and Chen Chen

et al . 2008 ), adipose tissue inflammation ( Pedersen et al . 2015 ), ectopic lipid accumulation in liver and muscle ( Morita et al . 2017 ), and the development of insulin resistance ( Samuel & Shulman 2016 ). Opposite to insulin, GH exhibits a

Free access

Mercedes Lombarte, Brenda L Fina, Maela Lupo, Marília A Buzalaf and Alfredo Rigalli

Introduction Sodium fluoride (NaF) is a bone anabolic drug ( Rigalli et al . 1992 ). However, chronic treatment with NaF produces insulin resistance (IR; Menoyo et al . 2008 , Chiba et al . 2012 ). This effect is observed in many parts of the

Free access

G Üçkaya, P Delagrange, A Chavanieu, G Grassy, M-F Berthault, A Ktorza, E Cerasi, G Leibowitz and N Kaiser

Introduction Type 2 diabetes results from failure to increase insulin secretion in the face of insulin resistance ( Cerasi 1995 , Kahn 2003 ). Studies in humans and animal models of type 2 diabetes show marked β-cell dysfunction