Search Results

You are looking at 101 - 110 of 334 items for :

Clear All
Restricted access

Breno Picin Casagrande, Daniel Vitor de Souza, Daniel Araki Ribeiro, Alessandra Medeiros, Luciana Pellegrini Pisani and Debora Estadella

of the triggers and one of the results of the pathways’ activation, since it promotes the cleavage of pro-IL1β into its active form via NLRP3-caspase1 ( Liu et al. 2017 , Jin & Fu 2019 ). Associated with hypoxia, lipopolysaccharides (LPS), and TNFα

Free access

Diego Safian, Eduardo N Fuentes, Juan Antonio Valdés and Alfredo Molina

, expression profiles, and hormonal regulation . Endocrinology 147 2399 – 2410 . doi:10.1210/en.2005-1570 . Kamei H Lu L Jiao S Li Y Gyrup C Laursen L Oxvig C Zhou J Duan C 2008 Duplication and diversification of the hypoxia

Free access

G Basini, S Bussolati, S E Santini, F Bianchi, M Careri, A Mangia, M Musci and F Grasselli

. 2000 ). Moreover, similar to 2-methoxyestradiol ( Becker et al . 2008 ), 2-OHE2, and 4-OHE2 could inhibit hypoxia-inducible factor-1α that has been documented to play a key role in the VEGFA-induced angiogenesis ( Basini et al . 2004 ). Further

Free access

Matthias Haase, Matthias Schott, Stefan R Bornstein, Ludwik K Malendowicz, Werner A Scherbaum and Holger S Willenberg

inhibiton of hypoxia inducible factor-1 by competitive binding to CBP/p300 ( Bhattacharya et al. 1999 , Freedman et al. 2003 ). CITED2 overexpression has been associated with oncogenic transformation and enhanced proliferation in different cell types

Open access

Andrea Mafficini and Aldo Scarpa

inactivating mutations in the namesake gene, which is a negative regulator of the of the hypoxia-induced pro-proliferative HIF1 gene, a downstream effector of the PI3K/mTOR pathway as well; the VHL gene has also been reported to be frequently inactivated by

Free access

A I Turner, B J Hosking, R A Parr and A J Tilbrook

to acute stress during late gestation. For example, fetal plasma concentrations of cortisol were elevated following haemorrhage ( Rose et al. 1978 ), hypotension ( Wood et al. 1982 ), hypoxia ( Giussani et al. 1994 ) and hypoxemia ( Gardner et

Free access

K L Franko, D A Giussani, A J Forhead and A L Fowden

of dexamethasone suppress pituitary adrenal function but augment the glycaemic response to acute hypoxia in fetal sheep during late gestation. Pediatric Research 47 684 –691. Forhead AJ , Poore KR, Mapstone J & Fowden

Free access

Laura D Brown

initiation complex. Under conditions of oxygen and energy restriction (depicted in pink), hypoxia-inducible factor (HIF), regulated in development and DNA damage responses 1 (REDD1), and 5′-AMP-activated protein kinase (AMPK) decrease the rates of protein

Open access

Colin P Sibley

). In pre-eclampsia, it is proposed that hypoxia and/or ischaemia-reperfusion lead to the release of free radicals and inflammatory mediators causing cellular stress in the syncytiotrophoblast (the placental epithelium) ( Powe et al . 2011 , Burton et

Free access

Charlotte Lawson, Jose M Vicencio, Derek M Yellon and Sean M Davidson

contribute to hypoxia-induced pulmonary hypertension. Here, the beneficial effect of mesenchymal stromal cells was shown to be mediated by the release of exosomes which suppressed hyperproliferative pathways including those mediated by STAT3 and the miR-17