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Neil Tanday, Peter R Flatt, Nigel Irwin and R Charlotte Moffett

incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), in T2DM have been linked to direct positive effects at the level of the endocrine pancreas. This includes, but not limited to, potentiation of glucose

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Hidetada Ogata, Yusuke Seino, Norio Harada, Atsushi Iida, Kazuyo Suzuki, Takako Izumoto, Kota Ishikawa, Eita Uenishi, Nobuaki Ozaki, Yoshitaka Hayashi, Takashi Miki, Nobuya Inagaki, Shin Tsunekawa, Yoji Hamada, Susumu Seino and Yutaka Oiso

Introduction Incretins, the gut hormones such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP1), which are secreted from enteroendocrine K-cells and L-cells, respectively, following meal ingestion stimulate

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Takaharu Maruyama, Kenichi Tanaka, Jun Suzuki, Hiroyuki Miyoshi, Naomoto Harada, Takao Nakamura, Yasuhisa Miyamoto, Akio Kanatani and Yoshitaka Tamai

). It was also reported that bile acid stimulated glucagon-like peptide-1 (GLP-1) secretion from STC-1 cells via Gpbar1/TGR5 ( Katsuma et al. 2005 ). GLP-1 is secreted from the L-cells in the intestine after meals and indirectly decreases blood glucose

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Dominique A Glauser and Werner Schlegel

, glucagon-like peptide-1 (GLP-1), or glucose-dependent insulinotropic polypeptide (GIP) ( Trumper et al. 2000 , 2001 , Wrede et al. 2002 , Buteau et al. 2006 ). The binding of IGF-I or insulin to their receptors results in the

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Bethany P Cummings, Ahmed Bettaieb, James L Graham, Kimber Stanhope, Fawaz G Haj and Peter J Havel

peroxisome proliferator receptor γ (PPARγ) and glucagon-like peptide 1 (GLP1). PPARγ is a nuclear receptor that is highly expressed in adipose tissue and macrophages and acts to upregulate the expression of factors involved in adipocyte differentiation and

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Yoon Sin Oh, Youn-Jung Lee, Yup Kang, Jaeseok Han, Oh-Kyung Lim and Hee-Sook Jun

-1 (GLP1), a potent gluco-incretin hormone, has an antidiabetic function. It enhances glucose-dependent insulin release, insulin biosynthesis, and β-cell proliferation and suppresses β-cell apoptosis ( Doyle & Egan 2007 ). Exendin-4, a GLP1 receptor

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Hiranya Pintana, Nattayaporn Apaijai, Nipon Chattipakorn and Siriporn C Chattipakorn

al . 2010 ). In this context, anti-diabetic agents such as rosiglitazone and glucagon-like peptide (GLP-1) have been reported to negate cognitive decline ( During et al . 2003 , Escribano et al . 2009 , Wang et al . 2011 ). Recently developed

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Carmen Sanz, Isabel Roncero, Patricia Vázquez, M Angeles Navas and Enrique Blázquez

glucose concentrations and peptides on GK gene promoter expression was tested in transiently transfected GT1-7 cells. Neither different glucose concentrations (2.8, 5.5, 10, or 20 mM) nor leptin (LEP), glucagon-like peptide 1 (GLP-1) or neuropeptide Y

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Weiwei Xu, Jamie Morford and Franck Mauvais-Jarvis

acting on β cells, to facilitate the effect of testosterone in a paracrine manner. For that reason, we explored the possibility that AR action in β cells amplifies GLP-1R signaling to increase cAMP production. We reasoned that because GLP-1 is secreted by

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Xiaoyi Ma, Fei Gao, Qi Chen, Xiuping Xuan, Ying Wang, Hongjun Deng, Fengying Yang and Li Yuan

et al . 2018 ). There were 20–30 islets per mouse examined ( n  = 5–8 mice/group). Table 1 Antibodies for immunodetection. Antibody Source Dilution Guinea pig anti-insulin ab7842, Abcam IF: 1:100 Rabbit anti-GLP