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Liselotte Fransson, Stephanie Franzén, Victoria Rosengren, Petra Wolbert, Åke Sjöholm and Henrik Ortsäter

P <0.05 was considered statistically significant. Results Corticosterone exposure induces obesity, dyslipidemia, ectopic steatosis, and hypertension Mice receiving corticosterone via their drinking water developed enlarged fat deposits ( Fig. 1 A and

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Raylene A Reimer, Gary J Grover, Lee Koetzner, Roland J Gahler, Michael R Lyon and Simon Wood

case of microvesicular lipidosis reduced even further when combined with S/MET. Hepatic steatosis is the first hit in a cascade of non-alcoholic fatty liver disease that can progress to fibrosis and end-stage liver disease ( Parnell et al . 2012

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Ya Pei, Honggui Li, Yuli Cai, Jing Zhou, Xianjun Luo, Linqiang Ma, Kelly McDaniel, Tianshu Zeng, Yanming Chen, Xiaoxian Qian, Yuqing Huo, Shannon Glaser, Fanyin Meng, Gianfranco Alpini, Lulu Chen and Chaodong Wu

Mashek DG , 2012 Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice . PLoS ONE 7 e39286 . ( ) 10.1371/journal.pone.0039286 22768070 Guo X Li H Xu H Halim V

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Jiali Liu, Yue Li, Xiaoyan Zhou, Xi Zhang, Hao Meng, Sanyuan Liu, Lei Zhang, Juntao He, Qian He and Yan Geng

, liver also plays a central role in the synthesis and degradation of fatty acids. To address the role of CaMKIV on glucose and lipid metabolism, mice were fasted 16 h before killing. We first analyzed mice liver weight and steatosis. These results showed

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Rosalba Senese, Federica Cioffi, Pieter de Lange, Fernando Goglia and Antonia Lanni

/kg BW) acutely. After 6 h, a significant increase in RMR was detected in both patients. Daily T 2 administration for 28 days increased RMR by ∼15% and decreased BW by about 4 kg. Ultrasonography revealed that one subject showed reductions in steatosis

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Zhengu Liu, Violeta Stanojevic, Luke J Brindamour and Joel F Habener

insulin resistance. This circumstance manifests in hyperglycemia, hyperlipidemia, hypertension, atherosclerosis, and steatosis of major organs such as the liver (nonalcoholic fatty liver disease), heart (lipotoxic cardiomyopathy), brain (Alzheimer

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Hsiu-Chi Lee and Shaw-Jenq Tsai

repression of β-oxidation. In experimental obesity models, intermittent hypoxia exposure worsens the insulin intolerance and hepatic steatosis. Hepatocyte-specific Hif-1α knockout mice fed with high-fat diet exhibit glucose intolerance. Hepatic ablation of

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Lianne Abrahams, Nina M Semjonous, Phil Guest, Agnieszka Zielinska, Beverly Hughes, Gareth G Lavery and Paul M Stewart

hepatic steatosis ( Tomlinson & Stewart 2005 ). 11β-HSD1 inhibitors are currently in phase II clinical trials ( Boyle & Kowalski 2009 ), and a number of animal studies have been conducted in which 11β-HSD1 inhibitors appear to have efficacy ( Alberts et

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Cid Pitombo, Eliana P Araújo, Cláudio T De Souza, José C Pareja, Bruno Geloneze and Lício A Velloso

AC & Velloso LA 2005b Short-term inhibition of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice. Diabetologia 48 1860 –1871

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Amanda E Brandon, Ella Stuart, Simon J Leslie, Kyle L Hoehn, David E James, Edward W Kraegen, Nigel Turner and Gregory J Cooney

Correa-Medina M Ueta C Kang HW Cohen DE Bianco AC 2011 Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality . Diabetes 60 1082