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Bethany P Cummings, Andrew A Bremer, Timothy J Kieffer, David D'Alessio and Peter J Havel

's syndrome) often exhibit hyperglycemia, hyperinsulinemia, and hepatic steatosis ( Howlett et al . 1985 ). Under normal physiological conditions, glucocorticoids function to protect against hypoglycemia during times of acute stress and/or reduced energy

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Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko and Nobuya Inagaki

in adipose tissue reduces insulin resistance and hepatic steatosis in high-fat diet-fed mice . Diabetes 66 868 – 879 . ( https://doi.org/10.2337/db16-0758 ) Kalyani RR Corriere M Ferrucci L 2014 Age-related and disease-related muscle

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Shannon M Bailey, Uduak S Udoh and Martin E Young

rats with forced activity in the normal active phase. Furthermore, this experimental protocol disrupted the normal daily rhythms in both clock and metabolic genes and caused hepatic steatosis ( Salgado-Delgado et al . 2013 ). Similarly, dim

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Jennifer H Steel, Roger White and Malcolm G Parker

accumulation in the liver on high-fat diet was seen in wild-type but not in RIPKO mice, showing that the absence of RIP140 protects against hepatic steatosis ( Leonardsson et al. 2004 ). WAT and BAT can be distinguished by the morphology of the

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Yu-Feng Zhao, Jianming Pei and Chen Chen

cell line INS-1E . Biochemical and Biophysical Research Communications 335 97 – 104 . Steneberg P Rubins N Bartoov-Shifman R Walker MD Edlund H 2005 The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired

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Pierre Roubert, Béatrice Dubern, Pascale Plas, Cécile Lubrano-Berthelier, Rohia Alihi, Florence Auger, Daniel B Deoliveira, Jesse Z Dong, Arnaud Basdevant, Christophe Thurieau and Karine Clément

-022493 improves hepatic steatosis reducing liver lipid and TG content in diet-induced obese mice ( Kumar et al . 2009 ). Those data suggest that MC4R agonists may have a protective effect on lipid metabolism and especially TG synthesis. In both

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Sachie Asamizu, Masaharu Urakaze, Chikaaki Kobashi, Manabu Ishiki, Amal Khalifa Norel Din, Shiho Fujisaka, Yukiko Kanatani, Agussalim Bukahari, Satoko Senda, Hikari Suzuki, Yuh Yamazaki, Minoru Iwata, Isao Usui, Katsuya Yamazaki, Hiroshi Ogawa, Masashi Kobayashi and Kazuyuki Tobe

Kitazawa R Kitazawa S Miyachi H Maeda S Egashira K 2006 MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity . Journal of Clinical Investigation 116 1494 – 1505 . Karlsson

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K Alexander H Iwen, Oezge Senyaman, Arne Schwartz, Maren Drenckhan, Britta Meier, Dirk Hadaschik and Johannes Klein

to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity . Journal of Clinical Investigation 116 1494 – 1505 . Klein J Fasshauer M Ito M Lowell BB Benito M Kahn CR 1999 β3-Adrenergic stimulation

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Martin Haluzík, Helena Kratochvílová, Denisa Haluzíková and Miloš Mráz

improvements in glucose tolerance and hepatic steatosis underscoring the significance of bile acid signaling in the metabolic effects of bariatric surgery ( Flynn et al . 2015 ). Numerous studies have indicated that malabsorptive operations markedly affect

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Clara Lefranc, Malou Friederich-Persson, Roberto Palacios-Ramirez and Aurelie Nguyen Dinh Cat

, decreases adipose tissue hypertrophy, hepatic steatosis and improves insulin sensitivity and adiponectin plasma levels. Moreover, the activity of the endogenous BAT was increased by the presence of the transplanted BAT. However, transplantation would be