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Marta Montolio, Montse Biarnés, Noèlia Téllez, Jessica Escoriza, Joan Soler and Eduard Montanya

), hypoxia of islets ( Dionne et al. 1993 ), the metabolic condition of the recipient ( Merino et al. 1997 ) and the absence of survival factors present in the non-endocrine pancreas ( Ilieva et al. 1999 ). In addition, non-specific inflammation at the

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Michela Campolo, Akbar Ahmad, Rosalia Crupi, Daniela Impellizzeri, Rossana Morabito, Emanuela Esposito and Salvatore Cuzzocrea

ones. Immediately following TBI, the direct trauma and the lack of blood flow cause necrotic neuronal death; however, even greater apoptotic neuronal loss occurs hours and days later, caused by secondary injury from cerebral ischemia/hypoxia as well as

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J E Digby, J Chen, J Y Tang, H Lehnert, R N Matthews and H S Randeva

using scissors to prevent tissue hypoxia. Tissue was then immediately transported and utilized for tissue culture within 1 h of excision. Prior to culture, tissue was further minced into approximately 1 mm 3 fragments and washed by pouring through a

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Qiong You, Zijun Wu, Bin Wu, Chang Liu, Ruina Huang, Li Yang, Runmin Guo, Keng Wu and Jingfu Chen

ATP channels affects cardiac action potentials under hypoxia ( Zhu et al . 2011 ); therefore, we hypothesized that the inhibition of cardiac K ATP channels might be a pivotal mechanism underlying HG-induced cardiomyocyte injury. To confirm our

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Bethany R L Aykroyd, Simon J Tunster and Amanda N Sferruzzi-Perri

manipulations including exercise, dexamethasone treatment, inhalation hypoxia and alcohol intake ( Cuffe et al. 2011 , 2014 , Gårdebjer et al. 2014 , Briffa et al. 2017 , Mangwiro et al. 2018 ). Maternal alcohol consumption in rats and dexamethasone

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Milos Mraz and Martin Haluzik

. Several mechanisms as to how increased amounts of AT may lead to metabolic derangements and enhanced atherosclerosis have been proposed, including endocrine dysfunction ( Bluher 2009 ), AT hypoxia ( Trayhurn 2013 ), or decreased lipid storage capacity with

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D S Boeldt and I M Bird

adaptation to pregnancy and disorders of PE are not just confined to the placenta itself. Different tissues and vascular beds may experience altered local and circulating hormones in unique ways based upon local environment (hypoxia, cell state and status of

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Sara Pepe, Márta Korbonits and Donato Iacovazzo

, which in turn causes an inhibition of prolyl-hydroxylases, leading to stabilisation of the hypoxia-inducible factor 1α (HIF1α) and transcription of HIF-responsive genes, some of which are involved in tumorigenesis, including, among others, VEGF and TGF

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Daniel M Kelly and T Hugh Jones

and pathophysiological conditions in human coronary artery smooth muscle cells and via AR-dependent and -independent mechanisms influenced by the physiological state of the cell ( Osterlund et al . 2010 ). DHT was also shown to suppress hypoxia

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Manuel C Lemos, Brian Harding, Anita A C Reed, Jeshmi Jeyabalan, Gerard V Walls, Michael R Bowl, James Sharpe, Sarah Wedden, Julie E Moss, Allyson Ross, Duncan Davidson and Rajesh V Thakker

abnormalities such as hypoxia, which may be secondary to the observed cardiac abnormalities of MH and PE ( Figs 4 and 5 ), and that such extra-hepatic metabolic abnormalities may contribute to the decrease in LS. Likewise, the cardiac abnormalities of MH and