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Terese M Zidon, Jaume Padilla, Kevin L Fritsche, Rebecca J Welly, Leighton T McCabe, Olivia E Stricklin, Aaron Frank, Youngmin Park, Deborah J Clegg, Dennis B Lubahn, Jill A Kanaley and Victoria J Vieira-Potter

M Handgraaf S Fabre A Raymond-Letron I Riant E Montagner A Vinel A Buscato M Smirnova N Fontaine C , 2017 Selective activation of estrogen receptor alpha activation function-1 is sufficient to prevent obesity, steatosis, and

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K A Walters, V Rodriguez Paris, A Aflatounian and D J Handelsman

hypersecretion frequently observed in PCOS women ( Dumesic et al. 2015 ). PCOS also has a substantial metabolic impact as it is strongly associated with obesity, metabolic syndrome, hyperinsulinemia, insulin resistance, dyslipidemia, hepatic steatosis and an

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Muraly Puttabyatappa, Robert M Sargis and Vasantha Padmanabhan

, oxidative stress, and hepatic steatosis ( Padmanabhan et al. 2010 b , Veiga-Lopez et al. 2013 , Puttabyatappa & Padmanabhan 2017 ). Similarly, animal models of gestational glucocorticoid administration have documented adverse fetal programming of the

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Stephanie R Thorn, Stig Purup, Mogens Vestergaard, Kris Sejrsen, Matthew J Meyer, Micheal E Van Amburgh and Yves R Boisclair

resistance, and hepatic steatosis in obesity . Journal of Clinical Investigation 116 1494 – 1505 . Kleinberg DL Feldman M Ruan W 2000 IGF-I: an essential factor in terminal end bud formation and ductal morphogenesis . Journal of Mammary Gland Biology

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Antonella Amato, Sara Baldassano, Rosa Liotta, Rosa Serio and Flavia Mulè

. Gupta NA Mells J Dunham RM Grakoui A Handy J Saxena NK Anania FA 2010 Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the

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Chun Zeng, Xin Yi, Danny Zipris, Hongli Liu, Lin Zhang, Qiaoyun Zheng, Krishnamurthy Malathi, Ge Jin and Aimin Zhou

steatosis and lipid droplets within renal tubular epithelial cell cytoplasm during their old age ( Fabre et al. 2012 ). To determine whether RNase L plays any role in the metabolic pathways, we fed RNase L + / + and RNase L − / − mice a high-fat diet for

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S Patterson, P R Flatt, L Brennan, P Newsholme and N H McClenaghan

also exerts toxic effects on pancreatic β-cells ( Prentki & Corkey 1996 ), partly through the accumulation of intra-cellular triacylglycerol (steatosis) ( Unger 1995 , Dixon et al. 2004 ). Indeed, β-cells with a high proportion of saturated fatty

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Tracy Josephs, Hayley Waugh, Ilona Kokay, David Grattan and Mary Thompson

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. PNAS 102 6086 –6091. Yang Q , Graham TE, Mody N, Preitner F, Peroni OD

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Jerzy Bełtowski, Grażyna Wójcicka and Hieronim Jakubowski

chosen to avoid the induction of hypertriglyceridemia, liver steatosis, and elevation of liver enzymes observed at higher doses of T0901317 (10–100 mg/kg). In preliminary experiments, we established that T0901317 administered at 1 mg/kg per day had no

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Li Wang, Yufeng Zhao, Baosong Gui, Rongguo Fu, Feng Ma, Jun Yu, Ping Qu, Lei Dong and Chen Chen

Rubins N Bartoov-Shifman R Walker MD Edlund H 2005 The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse . Cell Metabolism 1 245 – 258 doi:10.1016/j.cmet.2005.03.007 . Unger RH Orci