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Markus Meier, Harald H Klein, Jan Kramer, Maren Drenckhan and Morten Schütt

, genes encoding proteins with effects on insulin signaling and/or insulin action are of special interest in order to understand the underlying molecular mechanism of the insulin resistance and to develop effective treatments. Recent studies have

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Mariana Renovato Martins, Anatalia Kutianski Gonzalez Vieira, Érica Patrícia Garcia de Souza and Anibal Sanchez Moura

. 2003 ). Furthermore, the main source of energy changes from glucose to fatty acids in the adult heart ( Lopaschuk et al . 2007 ). During this developmental process, cellular insulin signaling is an important mechanism for cardiac development. It has

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Shaodong Guo

molecular, biochemical, and physiological levels. Part 1: molecular basis of insulin signaling Insulin and signal transduction studies have resulted in breakthroughs in the area of diabetes and biomedical research. Innovative attempts at insulin purification

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Daniela F Bertelli, Andressa Coope, Andrea M Caricilli, Patricia O Prada, Mario J Saad, Licio A Velloso and Eliana P Araujo

expression was increased in obese, insulin-resistant animals and the inhibition of its expression resulted in a significant improvement in insulin signal transduction and restoration of glucose homeostasis. Materials and methods Experimental animals All

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Raquel Barbuio, Marciane Milanski, Manoel B Bertolo, Mário J Saad and Lício A Velloso

activate intracellular serine kinases capable of targeting and inhibiting key elements of the insulin signaling pathway ( De Souza et al. 2005 a , Hotamisligil 2006 ). In the liver, both systemic and locally produced cytokines are thought to play a role

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M Schütt, J Zhou, M Meier and H H Klein

insulin signaling at the level of insulin-receptor substrate (IRS)-1 phosphorylation ( Schütt et al. 2000 , Cammalleri & Germinario 2003 ), association of the p85 subunit of phosphatidylinositol 3-kinase (PI3-kinase; Schütt et al. 2000 ) and/or Thr

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Patrícia Oliveira Prada, Michella Soares Coelho, Henrique Gottardello Zecchin, Miriam Sterman Dolnikoff, Alessandra Lia Gasparetti, Luzia Naôko Shinohara Furukawa, Mario José Abdalla Saad and Joel Claudio Heimann

the metabolic effects of insulin. Many mechanisms may contribute to the dysregulation of the insulin signaling pathway, including serine phosphorylation of IRS proteins by protein kinases such as c-jun N-terminal kinase (JNK) ( Lee et al

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Victor Wong, Linda Szeto, Kristine Uffelman, I George Fantus and Gary F Lewis

study was designed to investigate whether the previously demonstrated OMA-induced improvement in muscle glucose uptake is mediated by enhanced insulin signaling via known pathways of insulin signaling in skeletal muscle. Our results demonstrate that OMA

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Thangiah Geetha, Paul Langlais, Michael Caruso and Zhengping Yi

Introduction Insulin regulates a wide variety of biological processes, and defects in insulin signaling in skeletal muscle are considered to be one of the main causes for a large number of disease conditions, such as insulin resistance, metabolic

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A Tsuchiya, T Kanno and T Nishizaki

kinase 1 (Pak1; Mao et al . 2008 ), in a PI3K-independent manner. This study was conducted to gain further insight into PI3K-induced Akt activation in the insulin signal transduction pathway. To address this, we monitored GLUT4 mobilizations, measured