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T V Novoselova, D Jackson, D C Campbell, A J L Clark and L F Chan

expression in the hypothalamus. Melanocortin 2 receptor is a critical component of the HPA axis Melanocortin receptors (MCRs) are a subfamily of seven-transmembrane (TM)-domain G-protein-coupled receptors (GPCRs) that mediate signalling of hormones derived

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Stuart A Morgan, Zaki K Hassan-Smith, Craig L Doig, Mark Sherlock, Paul M Stewart and Gareth G Lavery

, including skeletal myopathy; highlighting 11β-HSD1 as a potential therapeutic target in the treatment of Cushing’s syndrome ( Morgan et al. 2014 ). Muscle mass is tightly controlled through the regulation of protein metabolism, myoblast proliferation

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Kenshiro Shikano, Eiko Iwakoshi-Ukena, Takaya Saito, Yuki Narimatsu, Atsuki Kadota, Megumi Furumitsu, George E Bentley, Lance J Kriegsfeld and Kazuyoshi Ukena

hypothalamic regulatory factors, we recently discovered a novel cDNA encoding the precursor of a small secretory protein in the chicken, rat, mouse and human brain ( Ukena et al. 2014 , Iwakoshi-Ukena et al. 2017 , Matsuura et al. 2017 , Ukena 2018

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Katherine A Staines, Vicky E MacRae and Colin Farquharson

movement and flexible to prevent fracture. The organic component of bone, termed the osteoid, comprises an extracellular matrix (ECM) primarily composed of collagen type I together with several non-collagenous proteins (NCPs). One such family of NCPs is the

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J Jeyabalan, M Shah, B Viollet and C Chenu

by the same hormones acting on receptors in the central nervous system (CNS). The latest demonstration of a feedback control by the skeleton of glucose and fat metabolism through the systemic release of the osteoblast-specific protein osteocalcin

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Geoffrey L Hammond

proteins regulate the non-protein-bound or ‘free’ fraction of steroid hormones in plasma, and control their ability to leave the blood vessels within tissues and to access their target cells ( Siiteri et al. 1982 ). Albumin binds all classes of steroids

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Kyriaki S Alatzoglou, Daniel Kelberman and Mehul T Dattani

. 2005 ). Subsequently, SOX2 was also found to be critical for the development of the hypothalamo–pituitary axis ( Kelberman et al . 2006 , 2008 ). In this review, we will focus on the role of SOX proteins as has been elucidated by transgenic animal

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Stefano Zanotti, Lisa Stadmeyer, Anna Smerdel-Ramoya, Deena Durant and Ernesto Canalis

Introduction CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that play a role in cell proliferation, differentiation, and apoptosis ( Nerlov 2007 ). Six members of the C/EBP family have been characterized and are

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Karen Oliva, Gillian Barker, Gregory E Rice, Mark J Bailey and Martha Lappas

and omental adipose tissues are characterised by differences in the expression of genes and proteins related to glucose and lipid metabolism, lipid transport and cellular stress and inflammation ( Linder et al . 2004 , Vohl et al . 2004 , Perez

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Magdalena Maj, Wolfgang Gartner, Aysegul Ilhan, Dashurie Neziri, Johannes Attems and Ludwig Wagner

the HUGO and MGI Databases) protein has attracted a lot of interest. TAU is important for microtubule dynamics ( Goedert & Jakes 1990 ) and axoplasmic transport ( LaPointe et al . 2009 ). AD is characterized by the occurrence of TAU deposits and