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Tatiana Dorfman, Yulia Pollak, Rima Sohotnik, Arnold G Coran, Jacob Bejar and Igor Sukhotnik

activates T-cell factor (TCF) and lymphoid enhancer factor to regulate the expression of Wnt target genes ( Schinner et al . 2009 ). Formation of a β-catenin/Tcf4 complex results in the direct upregulation of c- Myc , which in turn represses p21CIP1/WAF1 by

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Michael Rouse, Antoine Younès and Josephine M Egan

, Waddleton et al . 2008 ), PDE8B ( Dov et al . 2008 ), and PDE10A ( Cantin et al . 2007 ) expression enhances β-cell function by promoting insulin secretion in response to glucose in rat β-cells. Resveratrol (RES; 3,4′,5-trihydroxystilbene) is a

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Kotaro Azuma, Stephanie C Casey, Masako Ito, Tomohiko Urano, Kuniko Horie, Yasuyoshi Ouchi, Séverine Kirchner, Bruce Blumberg and Satoshi Inoue

understand the roles of SXR/PXR in the bone tissue more precisely. Our results demonstrated that loss of SXR/PXR enhanced bone resorption and reduced bone formation in the trabecular bones and decreased thickness in the cortical bones. Moreover, these mice

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Jee H Lee, Jamie L Volinic, Constanze Banz, Kwok-Ming Yao and Melissa K Thomas

activation ( Chakrabarti et al. 2003 ), and p300 interactions with the transcriptional regulators PDX-1 (pancreas duodenum homeobox-1), NeuroD1/Beta-2 and E47 enhance insulin gene transcription ( Qiu et al. 1998 , 2002 , Sharma et al. 1999 , Mosley

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S M J Scullion, E Gurgul-Convey, M Elsner, S Lenzen, P R Flatt and N H McClenaghan

. doi:10.1161/01.HYP.0000127811.48554.12 . Suhara T Fukuo K Yasuda O Tsubakimoto M Takemura Y Kawamoto H Yokoi T Mogi M Kaimoto T Ogihara T 2004 Homocysteine enhances endothelial apoptosis via upregulation of fas-mediated pathways

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Victor Wong, Linda Szeto, Kristine Uffelman, I George Fantus and Gary F Lewis

). The consequence of dual inhibition of NEP and ACE is a synergistic reduction in vasoconstriction and enhancement of vasodilation, thereby serving to reduce blood pressure (BP) more effectively than ACE inhibitors (ACEI). Of the VPIs, the most advanced

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Anna G Holmes, Jose L Mesa, Bronwyn A Neill, Jason Chung, Andrew L Carey, Gregory R Steinberg, Bruce E Kemp, Robert J Southgate, Graeme I Lancaster, Clinton R Bruce, Matthew J Watt and Mark A Febbraio

released ( Steensberg et al . 2001 ) from skeletal muscle during exercise, led to renewed interest in the role of IL-6 in the aetiology of insulin resistance because insulin action is enhanced in the immediate post-exercise period ( Wojtaszewski et al

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L Bai, G Meredith and B E Tuch

Introduction Glucagon-like peptide-1 (GLP-1) is a peptide secreted from the gut in response to food. It acts directly on β cells, enhancing the effect of glucose in stimulating insulin secretion from these cells. When administered to

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Shannon M Gifford, Fu-Xian Yi and Ian M Bird

redistribution of maternal blood flow. In particular, uterine artery blood flow increases dramatically and uterine artery endothelium function is altered to enhance vasodilator production in particular ( Bird et al. 2003 ). Uterine artery (UA) EC derived from

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Rebeca Martinez, Kenia Ubieta, Fidel Herrera, Alina Forellat, Reynold Morales, Ania de la Nuez, Rolando Rodriguez, Osvaldo Reyes, Ayme Oliva and Mario P Estrada

action of A233 to be GH-mediated. We also show the biological action in vivo of the molecule, for growth stimulation in goldfish and tilapia larvae and enhancing the level of some innate immune parameters and the superoxide dismutase (SOD) in tilapia