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Sara Baldassano, Anna Lisa Bellanca, Rosa Serio and Flavia Mulè

were in compliance with the guidelines of the European Communities Council Directive of 24 November 1986. Diets After 1 week of free access to a pelletized rodent diet (GLP4RF21; Mucedola, S.r.L. Italy), mice were divided into two groups. One group were

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K K Sidhu, R C Fowkes, R H Skelly and J M Burrin

Introduction Glucagon-like peptide 1 (GLP-1) is a proglucagon-derived peptide hormone that is synthesized and secreted by intestinal L-cells in response to the ingestion of nutrients and circulates to the pancreas where it stimulates

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L van Bloemendaal, J S ten Kulve, S E la Fleur, R G Ijzerman and M Diamant

), oxyntomodulin (OXM) and glucagon-like peptide 1 (GLP-1), have been identified as players in the regulation of feeding by relaying meal-related information on nutritional status to the brain. Based on more than three decades of experimental evidence from rodent

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Hongbin Liu, Yunshan Hu, Richard W Simpson and Anthony E Dear

Introduction Glucagon-like peptide-1 (GLP-1), an incretin first identified in 1984, has been proposed as a potential candidate target for therapy in the treatment of type 2 diabetes ( Nauck et al . 1993 , Edwards 2005 ). GLP-1, the product of the

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Neville H McClenaghan, Peter R Flatt and Andrew J Ball

-cell desensitisation compared with sulphonylureas may occur following prolonged exposure to nateglinide ( Ball et al. 2004 b ). In vivo , insulin secretion can be stimulated by glucagon-like peptide-1 (GLP-1), a hormone of the enteroinsular axis, released

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Antonella Amato, Sara Baldassano, Rosa Liotta, Rosa Serio and Flavia Mulè

Introduction Glucagon-like peptide 1 (GLP1), produced by intestinal enteroendocrine L-cells in response to the ingestion of nutrients ( Schirra et al . 1996 ), is highly insulinotropic and an inhibitor of gastrointestinal motility, effects that

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Raylene A Reimer

Introduction Glucagon-like peptide-1 (GLP-1) is a gut hormone released from intestinal L-cells in response to food ingestion ( Kieffer & Habener 1999 ). In addition to potentiating glucose-dependent insulin secretion, GLP-1

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Guillaume Mabilleau, Aleksandra Mieczkowska, Nigel Irwin, Peter R Flatt and Daniel Chappard

al . 2010 ). Glucagon-like peptide-1 (GLP1) is a gut hormone synthesized and secreted into the blood stream by intestinal endocrine L cells in response to a variety of stimuli ( Wu et al . 2010 ). Biologically active GLP1 is secreted as a 7–37 or 7

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Franca S Angeli and Richard P Shannon

worldwide epidemic, there is a growing demand for new treatments that not only control plasma glucose but also reduce macrovascular complications. Glucagon-like peptide 1 (GLP-1) is a peptide hormone synthesized in and secreted by enteroendocrine L cells in

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Thomas H Claus, Clark Q Pan, Joanne M Buxton, Ling Yang, Jennifer C Reynolds, Nicole Barucci, Michael Burns, Astrid A Ortiz, Steve Roczniak, James N Livingston, Kevin B Clairmont and James P Whelan

Introduction Glucagon-like peptide-1 (GLP-1) is a potent endogenous modulator of insulin secretion that is released by the L-cells in the crypts of the jejunum and ileum in response to a meal ( Kieffer & Habener 1999 ). Its function