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Sergio Di Meo, Susanna Iossa and Paola Venditti

biogenesis regulation was reached with the discovery of the transcription factors, nuclear respiratory factors 1 (NRF-1) ( Evans & Scarpulla 1990 ) and 2 (NRF-2) ( Virbasius et al. 1993 ). Further advancement was reached with the discovery of an inducible

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Laura Marroqui, Eva Tudurí, Paloma Alonso-Magdalena, Iván Quesada, Ángel Nadal and Reinaldo Sousa dos Santos

signaling cascades culminates with the activation of transcription factors and co-regulators encoded by both nucleus and mitochondria. From the nuclear side, nuclear respiratory factors 1 and 2 (NRF1 and NRF2) are the two major transcription factors

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Pongpan Tanajak, Siriporn C Chattipakorn and Nipon Chattipakorn

shown by increased 3 nitrotyrosine (3NT) and 4 hydroxynonenal (4HNE). Second, increased nuclear factor (erythroid derived 2) like 2 (Nrf2) activated CD36 expression was seen, which led to increased plasma lipid uptake and accumulation into the cells

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Eun Soo Lee, Mi-Hye Kwon, Hong Min Kim, Nami Kim, You Mi Kim, Hyeon Soo Kim, Eun Young Lee and Choon Hee Chung

-arginase 2, anti-cluster of differentiation 68 (CD68), anti-nuclear factor, erythroid 2 like 2 (NRF2), anti-heme oxygenase1 (HO1), anti-NOX2, and anti-NOX4 (Santa Cruz Biotechnology), anti-β-actin, anti-nephrin (Abcam), anti-phospho (p)-AMPK, anti-p-P38, anti

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Seul Gi Kang, Hyon-Seung Yi, Min Jeong Choi, Min Jeong Ryu, Saetbyel Jung, Hyo Kyun Chung, Joon Young Chang, Yong Kyung Kim, Seong Eun Lee, Hyeon-Woo Kim, Hoil Choi, Dong Seok Kim, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Chul-Ho Lee, Yuichi Oike and Minho Shong

, and Future Planning, Korea (NRF-2015R1A2A1A13000951). H W K was supported by grants from the NRF, funded by the Ministry of Science, ICT, and Future Planning (no. NRF-2015R1A5A1009024). H S Y was supported by the Basic Science Research Program, through

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Clara Lefranc, Malou Friederich-Persson, Roberto Palacios-Ramirez and Aurelie Nguyen Dinh Cat

mice and administration of eplerenone corrected this decrease ( Hirata et al. 2009 ). The Nrf2 transcription factor (or NFE2L2) regulates genes involved in antioxidant defenses, including hemooxygenase 1 (HO1), SOD3, glutathione peroxidase (GPX

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Xiwen Xiong, Xupeng Sun, Qingzhi Wang, Xinlai Qian, Yang Zhang, Xiaoyan Pan and X Charlie Dong

of PA-induced β-cell dysfunction and apoptosis ( Janikiewicz et al . 2015 ). A recent report has shown that SIRT6 can protect human mesenchymal stem cells from oxidative stress through regulation of nuclear factor erythroid 2-related factor 2 (NRF2

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Jin Sook Yoon, Hyun Jung Lee, Min Kyung Chae, Sang Yeul Lee and Eun Jig Lee

A Rajendrasozhan S Caito S Yang SR Megson IL Rahman I 2008 Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells . American Journal

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Chan-Juan Ma, Ai-Fang Nie, Zhi-Jian Zhang, Zhi-Guo Zhang, Li Du, Xiao-Ying Li and Guang Ning

. American Journal of Physiology. Endocrinology and Metabolism 293 E286 – E292 . ( doi:10.1152/ajpendo.00693.2006 ) Jeon WK Hong HY Kim BC 2011 Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the

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Aran Son, Namju Kang, Sue Young Oh, Ki Woo Kim, Shmuel Muallem, Yu-Mi Yang and Dong Min Shin

. One is receptor activator of nuclear factor-kappa B ligand (RANKL) secreted by osteoblasts. The other is macrophage-colony-stimulating factor (M-CSF) ( Takayanagi 2007 ). RANK receptor’s activation by RANKL leads to oscillations in intracellular Ca 2