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Jian-Ting Ke, Mi Li, Shi-Qing Xu, Wen-Jian Zhang, Yong-Wei Jiang, Lan-yun Cheng, Li Chen, Jin-Ning Lou and Wei Wu

may act upon the glomerular capillary receptor of AGE (RAGE), activate protein kinase C (PKC), initiate oxidation stress reactions and/or cause a large accumulation of – reactive oxygen species (ROS) and nitric oxide, all of which can injure the

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Helena C Barbosa, Silvana Bordin, Gabriel Anhê, Shanta J Persaud, James Bowe, Maria I Borelli, Juan J Gagliardino and Antonio C Boschero

1993 ), and in sucrose-induced insulin resistance ( Del Zotto et al . 1999 , 2000 , Gagliardino et al . 2003 ). Islet neogenesis associated protein (INGAP) was identified as the active part of a pancreatic protein complex isolated from normal

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Misuzu Yamashita, Fumio Otsuka, Tomoyuki Mukai, Hiroyuki Otani, Kenichi Inagaki, Tomoko Miyoshi, Junko Goto, Masahiro Yamamura and Hirofumi Makino

Introduction Bone morphogenetic proteins (BMPs), members of the transforming growth factor (TGF)-β superfamily, have established critical roles in governing various aspects of embryological development, including brain, heart, kidney, and eyes

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Ananda Malta, Júlio Cezar de Oliveira, Tatiane Aparecida da Silva Ribeiro, Laize Peron Tófolo, Luiz Felipe Barella, Kelly Valério Prates, Rosiane Aparecida Miranda, Ghada Elmhiri, Claudinéia Conationi da Silva Franco, Aryane Rodrigues Agostinho, Amanda Bianchi Trombini, Audrei Pavanello, Clarice Gravena, Latifa Abdennebi-Najar and Paulo Cezar de Freitas Mathias

have their etiology during fetal development ( Barker 2004 ). One very potent insult is malnourishment, including protein restriction, during pregnancy, which causes intrauterine growth restriction leading to newborns with low body weight (BW) and

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Márta Szaszák, Hung-Dar Chen, Hao-Chia Chen, Albert Baukal, László Hunyady and Kevin J Catt

has important physiological roles in a number of other cell types, including immune cells ( Hunyady & Catt 2006 ). Binding of AngII to AGTR1s initiates conformational changes that lead to an activation of G proteins, predominantly Gq11, and several

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Kerstin Krause, Stefan Karger, Sien-Yi Sheu, Thomas Aigner, Romy Kursawe, Oliver Gimm, Kurt-Werner Schmid, Henning Dralle and Dagmar Fuhrer

Introduction Aberrant processing of the amyloid precursor protein (APP) and its formation in plaques play a major role in Alzheimer's disease pathogenesis. Besides the central nervous system, APP is also highly expressed in the epidermis, the

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M G Gnanalingham, A Mostyn, J Wang, R Webb, D H Keisler, N Raver, M C Alves-Guerra, C Pecqueur, B Miroux, T Stephenson and M E Symonds

–pituitary–adrenal axis with respect to the regulation of cortisol production coincident with the rapid activation of uncoupling protein (UCP)-1, which is unique to brown adipose tissue (BAT) ( Clarke et al. 1997 a , Ricquier & Bouillaud 2000 ), and is followed by the

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Ming Lu, Erik Berglund, Catharina Larsson, Anders Höög, Lars-Ove Farnebo and Robert Bränström

range. In this sense, parathyroid cells are unique because intracellular Ca 2+ ([Ca 2+ ] i ) inhibits PTH secretion, instead of stimulating secretion as in other endocrine cell types ( Shoback et al . 1983 ). The calcium-sensing receptor (CaSR) is a G-protein

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Sinead N Kelly, T Joseph McKenna and Leonie S Young

growing number of coregulatory proteins have been identified as mediators and modulators of steroid receptor signalling. The most widely studied coactivators are steroid receptor coactivators (SRCs), members of the p160 family, which are critical

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Z H Liu, K Tsuchida, T Matsuzaki, Y L Bao, A Kurisaki and H Sugino

morphogenetic protein 7 (BMP-7). Direct binding of these ligands to ActRIIs promotes the recruitment of type I receptors to the complex, which in turn results in phosphorylation of type I receptors, activation of type I receptors, and downstream propagation of