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Patricia Joseph-Bravo, Lorraine Jaimes-Hoy and Jean-Louis Charli

compartamentalized in secretory granules with the rest of processing enzymes: PCs cleave at the carboxy end of a pair of basic residues, a carboxypeptidase cleaves the basic residues leaving the immediate precursor of TRH: gln-his-progly (black squares) and cryptic

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Patricia Joseph-Bravo, Lorraine Jaimes-Hoy, Rosa-María Uribe and Jean-Louis Charli

bioactive TSH. At the thyroid, TSH stimulates synthesis and release of T 4 that is modified at target tissues by deiodinases (e.g. D1 and D2). Physiological support for the existence of the hypothalamic control of pituitary–thyroid function started with the

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Motoyasu Satou, Yoshihiro Nishi, Akira Hishinuma, Hiroshi Hosoda, Kenji Kangawa and Hiroyuki Sugimoto

and colleagues also suggested that the shorter fragments did not compete for binding of full-length ghrelin in the human hypothalamus or pituitary. In this study, we show that synthetic human ghrelin can be truncated into shorter fragments, i.e. a

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Giulia Baldini and Kevin D Phelan

) from the nucleus to the cytosol, an effect that promotes transcription of POMC and increased expression of carboxypeptidase E (CPE) with increased processing of POMC to α-MSH, and suppression of food intake ( Kim et al. 2006 , Plum et al. 2009