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A L Ferry, D M Locasto, L B Meszaros, J C Bailey, M D Jonsen, K Brodsky, C J Hoon, A Gutierrez-Hartmann and S E Diamond

(leucine 7, isoleucine 8, tyrosine 17, phenylalanine 18 and methionine 20) are required for repression of the PRL promoter ( Diamond & Gutierrez-Hartmann 2000 ). The transcriptional activity of Pit-1 is dictated by the DNA

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R C M Simmen, J M P Pabona, M C Velarde, C Simmons, O Rahal and F A Simmen

including cell growth, differentiation, apoptosis, migration, and tumor formation ( Black et al . 2001 , Ghaleb et al . 2005 , Wang & Zhao 2007 , Pearson et al . 2008 ). Interestingly, family members can antagonize each other's transcriptional activity

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Mirja Rotinen, Jon Celay, Marta M Alonso, Aranzazu Arrazola, Ignacio Encio and Joaquin Villar

HSD17B8 promoter activity. After showing that E2 induces the transcriptional activity of the minimal promoter, it became important to explore whether or not these CCAAT boxes participate in E2-induced HSD17B8 promoter activity. Therefore, HepG2 cells

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Sharon Maor, Doris Mayer, Ronit I Yarden, Adrian V Lee, Rive Sarfstein, Haim Werner and Moshe Z Papa

(nucleotide 1 corresponds to the transcription start site) were employed. These plasmids include 2350, 476, 188, or 40 nucleotides of the 5′-flanking region, linked to 640 bp of the 5′-untranslated region of the rat IGF-IR gene. The basal promoter activities

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Akira Takeshita, Junko Igarashi-Migitaka, Noriyuki Koibuchi and Yasuhiro Takeuchi

luciferase activity from the control plasmid with onefold basal activity defined as luciferase activity in the absence of ligand and exogenous SXR. The results are expressed as mean± s.d . ( n =3). Transcriptional activation by NRs is mediated by ligand

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Audrey Lamirand, Martine Ramaugé, Michel Pierre and Françoise Courtin

. 2006 , Freitas et al . 2010 ). NF-κB is a transcription factor which is classically involved in LPS signaling pathways ( Chen & Greene 2004 ). An NF-κB inhibitor, i.e. sulfasalazine, partially inhibits LPS-induced D2 activity in human mesothelioma

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Gonzalo Alba, Consuelo Santa-María, María Edith Reyes-Quiroz, Rajaa El Bekay, Isabel Geniz, José Martín-Nieto, Elizabeth Pintado and Francisco Sobrino

. Although high concentrations of ROS are catatonic, they are now known to function as signal transducing molecules at lower concentrations, modulating indirectly the activity of many enzymes and transcription factors. Classical regulation of the activity of

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R L Moore, Y Dai and D V Faller

Deacetylase activity dependent Physiological function of SIRT1 Estrogen receptor SIRT1 inhibits ligand-independent activation Yes Represses transcription Androgen receptor SIRT1 regulates AR ability to transform prostate cells Yes Represses transcription

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Won Bae Kim, Christopher J Lewis, Kelly D McCall, Ramiro Malgor, Aimee D Kohn, Randall T Moon and Leonard D Kohn

-catenin act transcriptionally to inhibit TPO gene expression and also to get an idea of the molecular mechanism of Wnt-1/β-catenin’s inhibitory action, we conducted TPO-promoter reporter assays. In an attempt to grossly separate their activities, three

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Akhilesh K Pandey, Wei Li, Xiangling Yin, Douglas M Stocco, Paula Grammas and XingJia Wang

effects of Ca 2+ influx through L-type Ca 2+ channels on Star gene transcription and steroid production. It was also observed that Ca 2+ is an inhibitor of hCG-activated adenylate cyclase activity in MA-10 mouse Leydig cells ( Pereira et al . 1988