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Xiaonan Yan, Xiaonan Dai, Jing Wang, Nannan Zhao, Yugui Cui and Jiayin Liu

PCOS involves the interaction of environmental factors with impaired peripheral insulin signaling ( Diamanti-Kandarakis & Dunaif 2012 ). Women with PCOS do not typically have structural abnormalities of insulin receptors (IRs), fewer IRs, or altered

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Zhiguo Liu, Chun Yan Lim, Michelle Yu-Fah Su, Stephanie Li Ying Soh, Guanghou Shui, Markus R Wenk, Kevin L Grove, George K Radda, Weiping Han and Xiaoqiu Xiao

alterations of insulin signaling pathways in white adipose tissue (WAT) and skeletal muscle (SKM) in CTR and CPO mice under low-fat diet (LFD) and HFD. Materials and methods Animals and diets Male offspring of Swiss Webster mice were used in this study. All

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Anshu Gupta, Malathi Srinivasan, Supaporn Thamadilok and Mulchand S Patel

.05 compared with LC. Effect of HF diet on levels of appetite-regulating neuropeptides and components of leptin and insulin signaling Quantitative RT-PCR Although it has been shown that leptin and insulin signaling pathways in the hypothalamus play a pivotal

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Ralf Baumeister, Elke Schaffitzel and Maren Hertweck

sites for post-translational modification exist ( Lin et al. 2001 , Hertweck et al. 2004 ) (Fig. 3 ). In addition to insulin signaling, DAF-7/transforming growth factor-β (TGF-β) signaling also regulates DAF-16 nuclear localization specifically at

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Thomas Nicholson, Chris Church, Kostas Tsintzas, Robert Jones, Leigh Breen, Edward T Davis, David J Baker and Simon W Jones

effect of recombinant human vaspin on insulin signalling and glucose uptake in human skeletal muscle tissue. Materials and methods Human samples Gluteus maximus skeletal muscle, SAT and blood samples were obtained from 21 lean (BMI 22.8 ± 0

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Edward Park, Victor Wong, Xinyu Guan, Andrei I Oprescu and Adria Giacca

the skeletal muscle mainly via inhibition of tyrosine phosphorylation of insulin receptor substrate (IRS)-1 ( Kim et al . 2001 , 2004 b , Yu et al . 2002 ), which is a critical step in insulin signal transduction. This process is likely mediated by

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Mi-Hyun Kim, Jae-Hwan Jee, Sunyoung Park, Myung-Shik Lee, Kwang-Won Kim and Moon-Kyu Lee

-dependent degradation of β-catenin ( Yi et al . 2008 ). Furthermore, in human hepatocytes, granulosa cells, and C2C12 myotubes, metformin quickly leads to insulin receptor phosphorylation and enhances insulin signaling, e.g., phosphoinositide 3 kinase (PI3K), both in

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Jie Wei, Xia Sun, Yajie Chen, Yuanyuan Li, Liqiong Song, Zhao Zhou, Bing Xu, Yi Lin and Shunqing Xu

inhibitors. Protein concentration was determined using the BCA Protein Assay kit (Thermo Scientific, Rockford, IL, USA). For insulin signaling experiments, rat offspring were fasted overnight, anesthetized with pentobarbital, and received intraperitoneal

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Cho-Rong Bae, Kazuya Hasegawa, Sayaka Akieda-Asai, Yurie Kawasaki, Kazuyo Senba, Youn-Soo Cha and Yukari Date

responses of gastrointestinal hormones to food intake, glucose metabolism, and insulin signaling in male Wistar rats fed SP or CP on a 3-h restricted feeding schedule. We also evaluated energy intake, body weight, energy expenditure, and the amount of food

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Saranyapin Potikanond, Pinyada Rattanachote, Hiranya Pintana, Panan Suntornsaratoon, Narattaphol Charoenphandhu, Nipon Chattipakorn and Siriporn Chattipakorn

) resulted in impairment of osteoblastic insulin signaling, decreased osteoblastic proliferation, increased osteoblastic apoptosis, and can lead to osteoporosis in the jaw bone ( Pramojanee et al . 2013 ). Preclinical and clinical studies have reported that