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Mélissa Otis, Shirley Campbell, Marcel D Payet and Nicole Gallo-Payet

activation of protein kinase A ( Penhoat et al. 2001 , Gallo-Payet & Payet 2003 ). In addition, in the Y1 adrenocortical cell line, ACTH may also activate the mitogenic-activated protein kinase pathway, p42/p44 (p42/p44 mapk ; Watanabe et al. 1997

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M Shimizu, J T Dickey, H Fukada and W W Dickhoff

Introduction Circulating insulin-like growth factor-I (IGF-I) is bound to a family of six IGF-binding proteins (IGFBPs). Depending on the type of IGFBP and circumstance, they can either inhibit or enhance the growth-promoting actions

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Andrea Anedda, Eduardo Rial and M Mar González-Barroso

Introduction The uncoupling proteins (UCPs) are carriers that belong to the protein superfamily constituted by the metabolite transporters of the mitochondrial inner membrane. In mammals, there are five genes that encode proteins considered to be

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Joyce Wang, Qing Qiu, Maliha Haider, Michael Bell, Andrée Gruslin and Julian K Christians

bioavailability of which is aided by proteases ( Lala & Hamilton 1996 , Salamonsen 1999 ). One of the critical proteases involved in normal placental development is pregnancy-associated plasma protein-A (PAPPA; Sun et al . 2002 ), which is produced by human

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Ji-Eun Kim, Seung Eun Song, Yong-Woon Kim, Jong-Yeon Kim, Sung-Chul Park, Yoon-Ki Park, Suk-Hwan Baek, In Kyu Lee and So-Young Park

Introduction Adiponectin is an abundant adipocyte-derived plasma protein that exerts beneficial effects on insulin sensitivity and vascular function ( Matsuzawa 2005 ). Plasma adiponectin levels are decreased in obese/diabetic rodents and humans

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Dawid Szczepankiewicz, Ewa Pruszynska-Oszmalek, Przemyslaw Kaczmarek, Marek Skrzypski, Karolina Andralojc, Tatiana Wojciechowicz, Maciej Sassek and Krzysztof W Nowak

al . 2002 , Pritchard et al . 2002 ). In 1997, a protein with a high homology to agouti protein was identified and called agouti-related protein (AGRP). This protein is an antagonist to melanocortin receptors, mainly MC3R and MC4R ( Ollmann et al

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Thierry Métayé, Pierre Levillain, Jean-Louis Kraimps and Rémy Perdrisot

Introduction G-protein-coupled receptor kinases (GRKs) are serine/threonine protein kinases that control the desensitization process of G-protein-coupled receptor (GPCR) family ( Pitcher et al . 1998 ). The molecular events underlying a

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Lucie Tosca, Sabine Crochet, Pascal Ferré, Fabienne Foufelle, Sophie Tesseraud and Joëlle Dupont

. 1999 ). However, the precise mechanisms governing the rapid growth of follicles and their filling up with lipoproteins, according to the hierarchy, are poorly understood. Thus, we investigated the presence of AMP-activated protein kinase (AMPK) in the

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Ricardo Rodríguez-Calvo, Josefa Girona, Josep M Alegret, Alba Bosquet, Daiana Ibarretxe and Lluís Masana

. 2013 , Liu et al . 2013 ). Among these adipokines, fatty acid-binding protein 4 (FABP4) has recently been linked to cardiovascular and metabolic diseases. Additionally, FABP4 is highly expressed in macrophages, contributing to the development of

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Piya Sen Gupta, Natalia V Prodromou and J Paul Chapple

Introduction In 2003, it was recognized that mutations in proteins essential for normal cilia function underlie Bardet–Biedl syndrome (BBS, Ansley et al . 2003 ; for details on the function of BBS proteins see Box 1 ). Subsequently, cilia