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Mina Takahashi, Fumio Otsuka, Tomoko Miyoshi, Hiroyuki Otani, Junko Goto, Misuzu Yamashita, Toshio Ogura, Hirofumi Makino and Hiroyoshi Doihara

2. Estrogen and ER complex mediate the activation of proto-oncogenes and oncogenes, nuclear proteins, and other target genes. However, at present, there is no definite information of a direct effect of estrogen in the development of breast cancer

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Nariaki Fujimoto, Yukimi Akimoto, Tomoharu Suzuki, Shigeyuki Kitamura and Shigeru Ohta

understood in the mouse. Identification of the secreted proteins will be helpful in understanding prostate development and pathology. The rodent prostate consists of the ventral prostate (VP), lateral prostate (LP), dorsal prostate (DP), and anterior

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C S A Markides and J G Liehr

investigated the selective binding of 4-OHE 2 to binding proteins other than the described estrogen receptors in wild-type mice. Materials and Methods Materials [6,7- 3 H] E 2 (specific activity, 50 Ci/mmol) was

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S Jang and L S H Yi

messenger generation ( Kopf 2002 ). Since the mPR has not been unequivocally identified yet from boar spermatozoa, here we report a 71 kDa sperm membrane protein as a novel putative non-genomic mPR in boar spermatozoa employing Western blot and ligand blot

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Mitra Arianmanesh, Rebecca H McIntosh, Richard G Lea, Paul A Fowler and Kaïs H Al-Gubory

proteins are involved in CL function. Therefore, abnormal expression of luteal components may have adverse effects on the end target, the endometrium, leading to embryo–endometrial asynchrony, disruption of embryo implantation and failure to maintain

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S F Ahmed and C Farquharson

suppressor of cytokine signalling (SOCS) family has been proposed. This review will first describe SOCS proteins and the effects of the GH/insulin-like growth factor 1 (IGF1) axis on linear growth and skeletal development before describing the evidence that

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Teruo Sugawara, Eiji Nomura and Nobuhiko Hoshi

). Since the intermembrane space of mitochondria is hydrophilic, a transport system is needed for the entry of cholesterol into the inner membrane, where P450scc resides. Steroidogenic acute regulatory (StAR) protein, which mediates the rate-limiting step

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Claudia Gentili, Ricardo Boland and Ana Russo de Boland

cells (enterocytes), PTH initiates its effects by interacting with the heterotrimeric G protein-coupled receptor, PTHR1 ( Gentili et al. 2003 b ). The transduction of PTH signal through the plasma membrane of rat enterocytes involves both a Gs

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A L Ferry, D M Locasto, L B Meszaros, J C Bailey, M D Jonsen, K Brodsky, C J Hoon, A Gutierrez-Hartmann and S E Diamond

domain (TAD). These proteins can have distinct effects on the regulation of target gene expression, tumorigenesis, or the effectiveness of pharmacological approaches to cancer treatment (e.g. c-Jun vs v-Jun ( Jurdic et al. 1995 , Huguier et al. 1998

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Run Yu, Martha Cruz-Soto, Sergio Li Calzi, Hongxiang Hui and Shlomo Melmed

protein regulating chromosome separation ( Zou et al. 1999 , Nasmyth 2002 , Yu et al. 2003 ). Securin inhibits separase, which degrades the bonding proteins between sister chromatids at the metaphase-to-anaphase transition. Securin is proteolyzed by