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Sung-Soo Park, Yeon-Joo Lee, Sooyeon Song, Boyong Kim, Hyuno Kang, Sejong Oh and Eungseok Kim

Introduction Excessive fat accumulation in key metabolic tissues, including the liver and adipose tissue, is closely associated with metabolic disorders such as obesity, insulin resistance, diabetes, nonalcoholic hepatic steatosis

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Qiong Lv, Rufei Gao, Chuan Peng, Juan Yi, Lulu Liu, Shumin Yang, Danting Li, Jinbo Hu, Ting Luo, Mei Mei, Ying Song, Chaodong Wu, Xiaoqiu Xiao and Qifu Li

of KCs were increased and KCs were polarized to pro-inflammatory M1 dominant subtypes, while depletion of KCs polarization prevented the development of hepatic steatosis ( Huang et al . 2010 , Chen et al . 2012 ). Furthermore, blocking the anti

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Antonio Gonzalez-Bulnes, Susana Astiz, Cristina Ovilo, Clemente J Lopez-Bote, Raul Sanchez-Sanchez, Maria L Perez-Solana, Laura Torres-Rovira, Miriam Ayuso and Jorge Gonzalez

presence and severity of the histological features of steatohepatitis (steatosis, inflammation and/or ballooning injury) were based on the scoring system developed by Kleiner et al . (2005) . Statistical analyses Data were analysed using SPSS 19.0 (IBM

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Li Zhao, Chunfang Zhu, Meng Lu, Chi Chen, Xiaomin Nie, Buatikamu Abudukerimu, Kun Zhang, Zhiyuan Ning, Yi Chen, Jing Cheng, Fangzhen Xia, Ningjian Wang, Michael D Jensen and Yingli Lu

group; # P  < 0.05, vs GK + NS group. Liraglutide improved hepatic steatosis and reduced adipocyte size in fat depots Liraglutide injections or food restriction drastically reduced hepatic lipid accumulation in GK rats ( Fig. 5A and B

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Daniel M Kelly and T Hugh Jones

steatosis and intracellular fat in muscle cells as well as lack of exercise and genetic factors precipitate the development of insulin resistance. Insulin resistance in turn promotes the development of glucose intolerance, hypertriglyceridaemia, low HDL

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Eun Hee Koh, Ah-Ram Kim, Hyunshik Kim, Jin Hee Kim, Hye-Sun Park, Myoung Seok Ko, Mi-Ok Kim, Hyuk-Joong Kim, Bum Joong Kim, Hyun Ju Yoo, Su Jung Kim, Jin Sun Oh, Chang-Yun Woo, Jung Eun Jang, Jaechan Leem, Myung Hwan Cho and Ki-Up Lee

-1b ( Cpt-1b ), pyruvate dehydrogenase kinase 4 ( Pdk4 ) and peroxisome proliferator-activated receptor α ( Ppar α ) ( Fig. 5 F). Administration of AZD6925 prevents hepatic steatosis, increases mitochondrial biogenesis, and changes macrophage

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Tomoaki Hayakawa, Tomomi Minemura, Toshiharu Onodera, Jihoon Shin, Yosuke Okuno, Atsunori Fukuhara, Michio Otsuki and Iichiro Shimomura

macrophage infiltration in the fat pads ( Desarzens & Faresse 2016 ). In sharp contrast to adipocyte-specific MR-KO and GR-KO mice, obese myeloid-specific MR-KO mice exhibited improved glucose intolerance, insulin resistance and hepatic steatosis ( Zhang et

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Isabelle Vögeli, Hans H Jung, Bernhard Dick, Sandra K Erickson, Robert Escher, John W Funder, Felix J Frey and Geneviève Escher

as to the phenotypic expression of CYP27A1 depletion, i.e. hepatic steatosis in KO mice and its absence in the CTX patient. A recent study ( Ahmed et al . 2012 ) has shown an increased 5α-THF/THF ratio in patients with steatosis compared to controls

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Daniel J Tobiansky, George V Kachkovski, Reilly T Enos, Kim L Schmidt, E Angela Murphy and Kiran K Soma

( Brown et al. 2008 , Bray 2010 , Tappy & Lê 2010 , Friberg et al. 2011 ). Clinical and pre-clinical studies demonstrate that sucrose intake disrupts metabolic physiology, such as insulin insensitivity and hepatic steatosis (see Johnson et al

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Kook Hwan Kim and Myung-Shik Lee

). Furthermore, hepatic FGF21 actions such as alleviation of steatosis and suppression of hepatic glucose production were less pronounced in these mice, suggesting indirect FGF21 action on the liver. These findings suggest that both adipose tissue and the brain