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Risheng Ye, Min Ni, Miao Wang, Shengzhan Luo, Genyuan Zhu, Robert H Chow and Amy S Lee

et al . 2004 ). As both central nervous system and endocrine pancreas are essential for glucose homeostasis and energy metabolism ( Prentki & Nolan 2006 , Cota et al . 2007 ), we directly examined the role of IP3R1 in glucose metabolism using the

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Ishita Bakshi, Eurwin Suryana, Lewin Small, Lake-Ee Quek, Amanda E Brandon, Nigel Turner and Gregory J Cooney

these rats was stripped into white and red and were then incubated with radiolabelled glucose and 2-deoxy glucose to study glucose metabolism under basal conditions. Control leg EDL muscle strips had an average FBPase activity of 0.21 µmol/min/g of

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David P Macfarlane, Shareen Forbes and Brian R Walker

, 2007 ). The effects of glucocorticoids on glucose metabolism are well characterised and have been reviewed in detail previously ( Andrews & Walker 1999 ). For many genes involved in glucose metabolism, glucocorticoid effects oppose those of insulin. As

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Wenjing Wang, Lisa Upshaw, D Michael Strong, R Paul Robertson and JoAnna Reems

importance in maintaining glucose homeostasis. Signals that stimulate insulin release are derived from the intracellular metabolism of glucose, rather than from a ligand–receptor interaction ( Malaisse et al. 1979 ). This process triggers an acceleration of

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Guillermo Vazquez-Anaya, Bridget Martinez, José G Soñanez-Organis, Daisuke Nakano, Akira Nishiyama and Rudy M Ortiz

genes, THs have critical roles in the maintenance of glucose homeostasis ( Chidakel et al. 2005 , Villicev et al. 2007 , Brenta 2010 ). However, evidence suggests that TH may induce non-genomic effects that contribute to cellular metabolism

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Lewin Small, Henry Gong, Christian Yassmin, Gregory J Cooney and Amanda E Brandon

and 32°C. Interestingly, although the relationship between energy expenditure and intake is very clear ( Cannon & Nedergaard 2011 ), there have been a wide range of reported effects of housing temperature on fat mass and glucose metabolism. These

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Isabel C Greenman, Edith Gomez, Claire E J Moore and Terence P Herbert

in either metabolism or transcription (Fig. 2 ). This indicates that the acute regulation of metabolism and transcription are likely important for the β-cell to maintain the correct response to changes in glucose concentration. Further analysis

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Valerie M Harris, Sachin V Bendre, Francina Gonzalez De Los Santos, Alemu Fite, Ahmad El-Yaman El-Dandachli, Lyazat Kurenbekova, Abdul B Abou-Samra and Colleen Buggs-Saxton

sensing in the gonadotroph and whether GnRH regulates glucose metabolism in the gonadotroph. Glucose enters cells via the solute carrier family-2 (SLC-2) proteins, which are also commonly referred to as glucose transporters (GLUTs; Mueckler 1994 , Uldry

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Adina Maniu, Graham W Aberdeen, Terrie J Lynch, Jerry L Nadler, Soon O K Kim, Michael J Quon, Gerald J Pepe and Eugene D Albrecht

Introduction Estrogen has a fundamentally important role in the adult in regulating pancreatic islet beta-cell integrity and function and consequently the secretion and action of insulin important for the control of metabolism of glucose

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L Lundholm, G Bryzgalova, H Gao, N Portwood, S Fält, K D Berndt, A Dicker, D Galuska, J R Zierath, J-Å Gustafsson, S Efendic, K Dahlman-Wright and A Khan

in the above reports, after normalizing E 2 dose for body weight. The effects that we observe on glucose tolerance and insulin sensitivity following E 2 treatment are mediated via ERα , since PPT has effects similar to E 2 on glucose metabolism