Search Results

You are looking at 61 - 70 of 448 items for :

  • "Insulin signaling" x
Clear All
Free access

Lin Xia, Zhongqiu Wang, Ying Zhang, Xiao Yang, Yibei Zhan, Rui Cheng, Shiming Wang and Jianfa Zhang

). Insulin is an essential regulator of intermediary metabolism, and insulin signaling involves a cascade of events initiated by the binding of insulin to insulin receptor (IR) followed by receptor autophosphorylation and activation of receptor tyrosine

Free access

Cathy A Guo and Shaodong Guo

; TCA, tricarboxylic acid. Control of cardiac homeostasis by IRS-1 and IRS-2 The metabolic control by insulin is tightly coupled to the insulin signaling cascade ( Fig. 2 ). Over the past a few years, creation of insulin receptor

Free access

Maria H M Lima, Lílian C Souza, Luciana C Caperuto, Estela Bevilacqua, Alessandra L Gasparetti, Ricardo Zanuto, Mario J A Saad and Carla R O Carvalho

classic target tissues such as muscle and fat ( Dunaif 1997 , Legro et al. 1999 , Poretsky et al. 1999 ). However, the regulation of insulin signaling in ovaries of rats with PCOS has not yet been investigated. In the present study, we

Free access

Wenbin Shang, Ying Yang, Libin Zhou, Boren Jiang, Hua Jin and Mingdao Chen

activation of insulin signaling ( Edens et al . 2001 , Wang et al . 2006 , Zhang et al . 2008 ). It has been indicated that the structural diversity of ginsenosides may lead to the different effects ( Attele et al . 1999 ). Therefore, the effect of Rb 1

Free access

Sujith Rajan, Ganesh Panzade, Ankita Srivastava, Kripa Shankar, Rajesh Pandey, Durgesh Kumar, Sanchita Gupta, Abhishek Gupta, Salil Varshney, Muheeb Beg, Raj Kumar Mishra, Ravi Shankar and Anil Gaikwad

6 weeks after 8-h fasting. Before killing, blood was collected and then insulin (0.75 U/kg) was injected to sensitize the insulin signaling. Organs were collected and stored in liquid nitrogen. Metabolic experiments Intraperitoneal glucose

Free access

Maristela Mitiko Okamoto, Gabriel Forato Anhê, Robinson Sabino-Silva, Milano Felipe dos Santos Ferreira Marques, Helayne Soares Freitas, Rosana Cristina Tieko Mori, Karla Fabiana S Melo and Ubiratan Fabres Machado

reactions were performed in duplicate and a relative comparison to ND was made with appropriate cDNA. Resulting gene expression data were calculated and analyzed based on the method ( Pfaffl 2001 ). Insulin signaling proteins analysis by western blotting

Free access

Yuichi Kikuchi, Muneharu Yamada, Toshihiko Imakiire, Taketoshi Kushiyama, Keishi Higashi, Naomi Hyodo, Kojiro Yamamoto, Takashi Oda, Shigenobu Suzuki and Soichiro Miura

-resistant obese Zucker rats ( Jiang et al. 1999 ). In vascular smooth muscle cells, activation of RhoA/Rho-kinase, ROK-α, increased the association between Rho-kinase and IRS-1, leading to inhibition of insulin signaling ( Begum et al. 2002 ). Recently, it was

Free access

Milos Lazic, Fraser Aird, Jon E Levine and Andrea Dunaif

changes in BW and food intake (8 C, 8 T, 10 D; Fig. 1 ). Group-housed adult male rats at 65–70 days of age (16 C, 15 T, 16 D) were fasted overnight, anesthetized with CO 2 , weighed, and decapitated. In order to examine insulin signaling, roughly half of

Free access

Juthamard Surapongchai, Mujalin Prasannarong, Tepmanas Bupha-Intr and Vitoon Saengsirisuwan

be accompanied with disruptions of the insulin signaling pathway and the ACE2/ANG(1–7)/MasR axis. To address these issues, we investigated the extent to which ANGII infusion at a more commonly used dose (100 ng/kg/min; ANGII-100) and a high pressor

Free access

Yu Wu, Tingting Wu, Jun Wu, Lei Zhao, Qing Li, Zac Varghese, John F Moorhead, Stephen H Powis, Yaxi Chen and Xiong Z Ruan

on alternate days and were culled 14 weeks after the first injection. At termination, blood samples were taken for cytokines and lipid assays, and tissue samples were collected for further detection. For biochemical analysis of insulin signaling