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Junny Chan, Elizabeth H Rabbitt, Barbara A Innes, Judith N Bulmer, Paul M Stewart, Mark D Kilby and Martin Hewison

pregnancy with pluripotent effects on decidualization and implantation ( Arcuri et al. 1996 , 1997 ), placental development ( Malassine & Cronier 2002 ), fetal brain development, and lung maturation and parturition ( Challis et al. 2001 , Whittle et

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Peter J Hornsby

provided a very thorough review of the potential significance of adrenarche in human biology. He convincingly links DHEAS to increased brain development, extended life span, and decreased sexual dimorphism. These ideas indicate that the significance of

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Ke Cui, Giamal N Luheshi and Patricia Boksa

– 487 doi:10.1016/ . Boksa P 2010 Effects of prenatal infection on brain development and behavior: a review of findings from animal models . Brain, Behavior, and Immunity 24 881 – 897 doi:10.1016/j.bbi.2010

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Sylvia V H Grommen, Lutgarde Arckens, Tim Theuwissen, Veerle M Darras and Bert De Groef

for thyroid hormone receptors alpha and beta in brain development indicated by differential expression of receptor genes . EMBO Journal 10 269 – 275 . Di Fulvio M Coleoni AH Pellizas CG Masini-Repiso AM 2000 Tri-iodothyronine induces

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Geoffrey J Beckett and John R Arthur

3 to specific tissues and, particularly in humans, it also appears to provide a significant source of plasma T3. Among its other physiological roles, D2 is critical for regulating brain development, TSH secretion in the pituitary and adaptive

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Diana Choi, Stephanie A Schroer, Shun Yan Lu, Erica P Cai, Zhenyue Hao and Minna Woo

cytochrome c -mediated apoptosis disturbs normal brain development and lymphocyte homeostasis ( Hao et al . 2005 ). However, the role of this apoptotic pathway in pancreatic β-cells was not assessed. The mitochondria are central to the maintenance of β

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XingJia Wang, Chwan-Li Shen, Matthew T Dyson, Xianling Yin, Randolph B Schiffer, Paula Grammas and Douglas M Stocco

during fetal brain development in the rat-validation by semi-quantitative RT-PCR. Brain Research. Developmental Brain Research 156 38 –45. Ascoli M 1981 Characterization of several clonal lines of cultured Leydig tumor

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Toya M Albury-Warren, Veethika Pandey, Lina P Spinel, Michal M Masternak and Deborah A Altomare

.1128/MCB.26.7.2772-2781.2006 ) Tschopp O Yang ZZ Brodbeck D Dummler BA Hemmings-Mieszczak M Watanabe T Michaelis T Frahm J Hemmings BA 2005 Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in

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George Schlossmacher, Adam Stevens and Anne White

1998 Apaf1 is required for mitochondrial pathways of apoptosis and brain development . Cell 94 739 – 750 . doi:10.1016/S0092-8674(00)81733-X .

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Michela Campolo, Akbar Ahmad, Rosalia Crupi, Daniela Impellizzeri, Rossana Morabito, Emanuela Esposito and Salvatore Cuzzocrea

brain development: some guidelines for understanding actions of pseudohormones and other toxic agents . Environmental Health Perspectives 74 177 – 184 . ( doi:10.1289/ehp.8774177 ) Mesenge C Margaill I Verrecchia C Allix M Boulu RG