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Anne-Marie O'Carroll, Stephen J Lolait, Louise E Harris and George R Pope

affect cardiac hypertrophy. G protein-coupling of APJ APJ was originally hypothesised to couple to G i/o based on initial experiments showing that forskolin-stimulated cAMP production is suppressed by apelin-13 ( Tatemoto et al . 1998 ). This coupling

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Fausto Bogazzi, Dania Russo, Francesco Raggi, Mohammad Bohlooly-Y, Jan Tornell, Chiara Sardella, Martina Lombardi, Claudio Urbani, Luca Manetti, Sandra Brogioni and Enio Martino

. Yussman MG Toyokawa T Odley A Lynch RA Wu G Colbert MC Aronow BJ Lorenz JN Dorn GW II 2002 Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy . Nature Medicine 8 725 – 730

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Xiwen Xiong, Xupeng Sun, Qingzhi Wang, Xinlai Qian, Yang Zhang, Xiaoyan Pan and X Charlie Dong

Metabolism 25 620 – 627 . ( doi:10.1016/j.tem.2014.08.005 ) Lu J Sun D Liu Z Li M Hong H Liu C Gao S Li H Cai Y Chen S 2016 SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of

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Christopher J Charles, Miriam T Rademaker and A Mark Richards

1997 Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure on tissue concentration and molecular forms. Journal of Endocrinology 155 541 –550. Rademaker MT

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Tsun-Jui Liu, Hui-Chin Lai, Chih-Tai Ting and Ping H Wang

survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96 857 –868. Dorn GW & Force T 2005 Protein kinase cascades in the regulation of cardiac hypertrophy. Journal of Clinical Investigation

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Peter Kolkhof and Lars Bärfacker

1942, he reported that desoxycorticosterone (as the acetate, DOCA), a precursor of aldosterone that was crystallized a decade later, induces nephrosclerosis accompanied by cardiac hypertrophy in animals ( Selye 1942 ). Later, Selye found that

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Pongpan Tanajak, Hiranya Pintana, Natthaphat Siri-Angkul, Juthamas Khamseekaew, Nattayaporn Apaijai, Siriporn C Chattipakorn and Nipon Chattipakorn

infarction (MI) ( Liu et al . 2012 , 2013 , Joki et al . 2015 ) and cardiac hypertrophy ( Planavila et al . 2013 , 2014 ). Interestingly, an increase in FGF21 levels is associated with future cardiovascular risk in T2DM patients ( Shen et al . 2013

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Danielle Brown, Amiya P Sinha Hikim, Ekaterina L Kovacheva and Indrani Sinha-Hikim

Q Mollkentin JD 2003 Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models . Journal of Molecular and Cellular Cardiology 35 1385 – 1394 . Lin A Dibling B 2002

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Shi-Yan Li, Cindy X Fang, Nicholas S Aberle II, Bonnie H Ren, Asli F Ceylan-Isik and Jun Ren

2002 Glycogen synthase kinase-3 beta: a novel regulator of cardiac hypertrophy and development. Circulation Research 90 1055 –1063. Hofmann PA , Menon V & Gannaway KF 1995 Effects of diabetes on isometric tension as a

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Adam Gesing, Andrzej Bartke and Michal M Masternak

anti-diabetic effects of TZDs ( Nawrocki et al . 2006 ). Furthermore, the suppressive effects of PIO on angiotensin II-induced cardiac hypertrophy, as were seen in wild-type mice, were diminished in adiponectin-deficient mice ( Li et al . 2010