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Bettina A Ikenasio-Thorpe, Bernhard H Breier, Mark H Vickers and Mhoyra Fraser

). Leptin is secreted mainly from adipose tissue and acts both in the brain and in the peripheral tissues. Five alternatively spliced forms of the leptin receptor are produced (OBRa–e), of which only OBRb has a long cytoplasmic region that is required for

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Z A Archer, S M Rhind, P A Findlay, C E Kyle, M C Barber and C L Adam

by insulin or leptin is likely to involve interneurons, since GnRH neurons do not express the leptin receptor (OB-Rb) (monkeys: Finn et al. 1998 ; rats: Hakansson et al. 1998 ), and there are no reports of GnRH cells expressing the insulin

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Ding Xie and Wendy B Bollag

distributed receptors ( Rondinone 2006 ). It has been previously demonstrated that leptin receptors are expressed in human and rat adrenal glomerulosa cells ( Ehrhart-Bornstein et al . 2003 ), although available data on the direct effects of leptin on

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Jeffrey Friedman

locomotor activity, are quite gentle and non-aggressive, and are not sexually active. Thus, the identification of leptin and later the localization of the leptin receptor ( Tartaglia et al . 1995 , Lee et al . 1996 ), encoded by the db gene, have

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Kenneth A Philbrick, Carmen P Wong, Adam J Branscum, Russell T Turner and Urszula T Iwaniec

Introduction Leptin, the protein product of the ob gene, is produced primarily by adipocytes and secreted into the vascular circulation in proportion to fat stored in adipose depots ( Jequier 2002 ). Leptin receptors are widely expressed in

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María F Andreoli, Jose Donato Jr, Isin Cakir and Mario Perello

negative feedback loops such as SOCS3 and PTP1B. ERK, extracellular signal-regulated kinase; JAK2, Janus kinase 2; LepRb, leptin receptor b; MAPK, mitogen-activated protein kinase; PI3K, phosphatidylinositol 3-kinase; SHP2, Src homology 2-containing

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R G P Denis, C Bing, S Brocklehurst, J A Harrold, R G Vernon and G Williams

al. 2000 , Williams et al. 2001 ). Leptin apparently modulates its own effects within the hypothalamus, as it inhibits the expression of the ‘b’ isoform of the leptin receptor (Ob-Rb) and induces down-regulation of the receptor protein

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Stefan O Krechowec, Mark Vickers, Arieh Gertler and Bernhard H Breier

functional leptin receptors develop severe obesity and hyperphagia ( Pelleymounter et al. 1995 , Lee et al. 1996 , Montague et al. 1997 ). However, in most obese conditions, plasma leptin is elevated well above levels that should suppress food intake

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Dawn E W Livingstone, Sarah L Grassick, Gillian L Currie, Brian R Walker and Ruth Andrew

leptin resistant db/db mice ( Liu et al . 2005 ). These differences may reflect the distinctions between the defects in leptin signalling in these models. Leptin signals through several splice variants of the leptin receptor (Ob-R; Lee et al . 1996

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Carmen Fanjul, Jaione Barrenetxe, Lorena De Pablo-Maiso and María Pilar Lostao

-term regulation of the Na + /glucose cotransporter SGLT1 ( Lostao et al . 1998 ). We later determined that leptin receptors were expressed in both apical and basolateral membranes of human and murine enterocytes ( Barrenetxe et al . 2002 ). In the same year