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Sofianos Andrikopoulos, Christine M Massa, Kathryn Aston-Mourney, Alexandra Funkat, Barbara C Fam, Rebecca L Hull, Steven E Kahn and Joseph Proietto

. Chong MM , Thomas HE & Kay TW 2002 Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor. Journal of Biological Chemistry 277 27945 –27952. Coleman DL & Hummel

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Teresa Priego, Miriam Granado, Estibaliz Castillero, Ana Isabel Martín, M Ángeles Villanúa and Asunción López-Calderón

( Peinnequin et al. 2004 ), suppressor of cytokine signaling-3 (SOCS-3) forward: CCTCCAG-CATCTTTGTCGGAAGAC; SOCS-3 reverse: TACTGG-TCCAGGAACTCCCGAATG; hypoxanthine–guanine phosphorybosyl transferase (Hprt) forward: CTCATG-GACTGATTATGGACAGGAC; Hprt reverse

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M K Piya, P G McTernan and S Kumar

in adipose tissue and hepatic tissue, IL6 is shown to be a pro-inflammatory adipokine. It increases insulin resistance by up-regulating suppressor of cytokine signalling 3 (SOCS3), which, in turn, impairs insulin-induced insulin receptor and IRS1

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Sharon H Chou and Christos Mantzoros

-Haschimi et al . 2000 ), impaired leptin signaling by suppressor of cytokine signaling 3 (SOCS3; Bjorbaek et al . 1998 , Dunn et al . 2005 ), impaired leptin receptor trafficking ( Bjornholm et al . 2007 , Morrison et al . 2007 ), saturation of leptin

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Mark O Huising, Corine P Kruiswijk and Gert Flik

members of the suppressor of cytokine signalling (SOCS) family. Currently the SOCS family consists of eight members (SOCS1–7 and cytokine-inducible SH2-containing domain (CIS)); the role of SOCS4–7 in cytokine signalling has received limited attention. The

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Lenka Maletínská, Andrea Popelová, Blanka Železná, Michal Bencze and Jaroslav Kuneš

, a decrease in Akt activation through an increase in suppressor of cytokine signaling (SOCS3) was linked to an inefficient leptin signaling ( King et al . 2018 ). Figure 2 Scheme of potential neuroprotective effects of anorexigenic peptides

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Russell T Turner, Michael Dube, Adam J Branscum, Carmen P Wong, Dawn A Olson, Xiaoying Zhong, Mercedes F Kweh, Iske V Larkin, Thomas J Wronski, Clifford J Rosen, Satya P Kalra and Urszula T Iwaniec

the hypothalamus due to constitutive expression of suppressor of cytokine signaling (hypothalamic resistance) ( Bjorbaek et al . 1998 ). Delivery of leptin directly into the hypothalamus by gene therapy normalizes body weight and extends lifespan in

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Lorena González, Ma. Eugenia Díaz, Johanna G Miquet, Ana I Sotelo, Diego Fernández, Fernando P Dominici, Andrzej Bartke and Daniel Turyn

context, breast cancer cells overexpressing the estrogen receptor ( Boerner et al . 2005 ). The activation of the STATs is highly regulated but incompletely understood. GRB2 and suppressors of cytokine signaling (SOCS) can inhibit STAT-mediated EGFR

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Rajat Kumar Das, Sarmistha Banerjee and Bernard H Shapiro

contradiction with the accompanying ∼90% decline in CYP2C11 mRNA and protein. However, the episodic GH/JAK2/STAT5B signal transduction pathway is negatively regulated by tyrosine phosphatases ( Frank 2001 , Waxman & O'Connor 2006 ) and suppressors of cytokine

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María E Díaz, Johanna G Miquet, Soledad P Rossi, Pablo E Irene, Ana I Sotelo, Mónica B Frungieri, Daniel Turyn and Lorena González

number of subsets ( n ) of individual animals. Different letters denote significant differences ( P ≤0.05). Representative western blots are shown. The liver content of the suppressor of cytokine signaling CIS also varies depending on GH plasma