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S Eleswarapu and H Jiang

al. 1997 ), the acid labile subunit (ALS) of the IGF binding complex ( Ooi et al. 1997 ), serine protease inhibitor (Spi) 2.1 ( Yoon et al. 1990 ), suppressors of cytokine signaling (SOCS) genes ( Tollet-Egnell et al. 1999 ), phosphoenol

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Bettina A Ikenasio-Thorpe, Bernhard H Breier, Mark H Vickers and Mhoyra Fraser

reduced signal transducer and activator of transcription-3 (STAT-3) activation, and involving increased expression of suppressor of cytokine signalling-3 (SOCS-3), an inhibitor of leptin signalling ( Munzberg et al. 2004 ). Our observation of increased

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Sharon H Chou and Christos Mantzoros

-Haschimi et al . 2000 ), impaired leptin signaling by suppressor of cytokine signaling 3 (SOCS3; Bjorbaek et al . 1998 , Dunn et al . 2005 ), impaired leptin receptor trafficking ( Bjornholm et al . 2007 , Morrison et al . 2007 ), saturation of leptin

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M K Piya, P G McTernan and S Kumar

in adipose tissue and hepatic tissue, IL6 is shown to be a pro-inflammatory adipokine. It increases insulin resistance by up-regulating suppressor of cytokine signalling 3 (SOCS3), which, in turn, impairs insulin-induced insulin receptor and IRS1

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Mark O Huising, Corine P Kruiswijk and Gert Flik

members of the suppressor of cytokine signalling (SOCS) family. Currently the SOCS family consists of eight members (SOCS1–7 and cytokine-inducible SH2-containing domain (CIS)); the role of SOCS4–7 in cytokine signalling has received limited attention. The

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Lenka Maletínská, Andrea Popelová, Blanka Železná, Michal Bencze and Jaroslav Kuneš

, a decrease in Akt activation through an increase in suppressor of cytokine signaling (SOCS3) was linked to an inefficient leptin signaling ( King et al . 2018 ). Figure 2 Scheme of potential neuroprotective effects of anorexigenic peptides

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Lorena González, Ma. Eugenia Díaz, Johanna G Miquet, Ana I Sotelo, Diego Fernández, Fernando P Dominici, Andrzej Bartke and Daniel Turyn

context, breast cancer cells overexpressing the estrogen receptor ( Boerner et al . 2005 ). The activation of the STATs is highly regulated but incompletely understood. GRB2 and suppressors of cytokine signaling (SOCS) can inhibit STAT-mediated EGFR

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N David Åberg, Inger Johansson, Maria A I Åberg, Johan Lind, Ulf E Johansson, Christiana M Cooper-Kuhn, H Georg Kuhn and Jörgen Isgaard

RL Coonan JR Bartlett PF 2002 Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling . Nature Neuroscience 5 1155 – 1162 . Westenbroek C Den Boer JA Veenhuis M Ter Horst GJ

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Lisa Rice, Charlotte E Waters, Jennifer Eccles, Helen Garside, Paula Sommer, Paul Kay, Fiona H Blackhall, Leo Zeef, Brian Telfer, Ian Stratford, Rob Clarke, Dave Singh, Adam Stevens, Anne White and David W Ray

  EMR1 2015 207111_at −2.0 0.185 EGF-like module containing, mucin-like, hormone receptor-like 1   SOCS3 9021 227697_at −1.9 0.198 Suppressor of cytokine signalling 3   LRP12 29 967 220254_at −1.9 0.143 Low density lipoprotein-related protein 12   RGS17

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Lorena González, Johanna G Miquet, Pablo E Irene, M Eugenia Díaz, Soledad P Rossi, Ana I Sotelo, Mónica B Frungieri, Cristal M Hill, Andrzej Bartke and Daniel Turyn

.mrrev.2009.01.001 ) Wu WY Kim H Zhang CL Meng XL Wu ZS 2014 Loss of suppressors of cytokine signaling 3 promotes aggressiveness in hepatocellular carcinoma . Journal of Investigative Surgery 27 197 – 204 . ( doi:10