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T C Alba-Loureiro, S M Hirabara, J R Mendonça, R Curi and T C Pithon-Curi

impaired function of these cells in diabetes. In the present study, the metabolism of glucose and glutamine in neutrophils obtained from streptozotocin (STZ)-induced diabetic rats was investigated. Key enzyme activities of glycolysis (hexokinase and

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W S Zawalich, H Yamazaki, K C Zawalich and G Cline

interacts with glucose-derived glycolytic or pentose cycle signals, metabolic pathways unique to glucose but not amino acid metabolism. It is interesting to note that, more than 25 years ago, Ammon and coworkers ( Akhtar et al. 1977 ) reported that insulin

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B Maiztegui, M I Borelli, M L Massa, H Del Zotto and J J Gagliardino

glucokinase (GK) activity, together with a marked increase of glucose metabolism in response to glucose ( Massa et al. 2001 ). It was not clear, however, whether the changes recorded in HK activity were accompanied by parallel changes in the transcription

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Luiz F Rezende, Luiz F Stoppiglia, Kleber L A Souza, Alessandro Negro, Francesco Langone and Antonio C Boschero

discarded and the islets incubated for a further period of 1 h in 1 ml KHBS containing 2.8 or 16.7 mM glucose. The supernatant was collected and insulin was measured by RIA. Glucose metabolism Batches of 50 islets each

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Juliane K Czeczor, Amanda J Genders, Kathryn Aston-Mourney, Timothy Connor, Liam G Hall, Kyoko Hasebe, Megan Ellis, Kirstie A De Jong, Darren C Henstridge, Peter J Meikle, Mark A Febbraio, Ken Walder and Sean L McGee

. 2014 ). However, greater amyloidogenic APP processing appears to have deleterious effects on cellular metabolism. Indeed, it has been recognised for some time that Aβ can impair neuronal glucose metabolism through a variety of mechanisms ( Meier

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Eriko Inoue, Toshihiro Ichiki, Kotaro Takeda, Hirohide Matsuura, Toru Hashimoto, Jiro Ikeda, Aya Kamiharaguchi and Kenji Sunagawa

BPS may be beneficial for the improvement of obesity-induced insulin resistance, in which inflammation plays an important role. We showed in this study that BPS improved glucose metabolism in association with reduction of inflammation of white adipose

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Antonella Amato, Sara Baldassano and Flavia Mulè

al . 1988 ); however, recent experimental data suggest that GLP2 exerts beneficial effects on glucose metabolism, especially in conditions related to increased uptake of energy, such as obesity, at least in the animal model ( Cani et al . 2009

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A E Andreazzi, D X Scomparin, F P Mesquita, S L Balbo, C Gravena, J C De Oliveira, W Rinaldi, R M G Garcia, S Grassiolli and P C F Mathias

experimental evidence indicates that glucose may also be stimulating insulin secretion by alternative pathways to K ATP channels ( Szollosi et al . 2007 ). Besides these mechanisms that involve stimulation of the metabolism, β-cells are also subjected to

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Ivonne Gisèle Makom Ndifossap, Francesca Frigerio, Marina Casimir, Florence Ngueguim Tsofack, Etienne Dongo, Pierre Kamtchouing, Théophile Dimo and Pierre Maechler

-cells and the action of insulin on its target tissues. In the consensus model of glucose-stimulated insulin secretion, glucose phosphorylation initiates its metabolism ( Iynedjian 2009 ), ultimately leading to plasma membrane depolarisation ( Ashcroft 2006

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Liisa Ailanen, Suvi T Ruohonen, Laura H Vähätalo, Katja Tuomainen, Kim Eerola, Henriikka Salomäki-Myftari, Matias Röyttä, Asta Laiho, Markku Ahotupa, Helena Gylling and Eriika Savontaus

. 2014). In the current study, we aimed to elucidate the effects of noradrenergic NPY on hepatic FA, cholesterol and glucose metabolism, to define their contribution to the development of the hepatosteatosis, hypercholesterolemia and IGT, and finally, to