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Manish V Sheth, Connie J Mark and Kathleen M Eyster

Introduction The importance of protein phosphatases in cellular function is increasingly recognized ( Cohen 1989 , Brautigan 1994 , Shenolikar 1994 , Gallego & Virshup 2005 ), although protein kinases continue to receive more

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C H J Verhoelst, V M Darras, S A Roelens, G M Artykbaeva and S Van der Geyten

protein is localized in brain cells, more specifically in astrocytes and tanycytes in the rat hypothalamus. Their results were in agreement with previously reported data on the mRNA distribution of rat D2. Guadaño-Ferraz et al. (1997) reported in situ

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Bradley S Miller, James T Bronk, Takayuki Nishiyama, Hiroshi Yamagiwa, Alok Srivastava, Mark E Bolander and Cheryl A Conover

ligands and specific receptors mediating the anabolic response, but also IGF-binding proteins (IGFBPs) and IGFBP proteases that ultimately determine the response ( Rechler & Clemmons 1998 , Bunn & Fowlkes 2003 , Duan & Xu 2005 ). To our knowledge, there

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Terhi J Heino, Andrei S Chagin and Lars Sävendahl

et al . 2001 ). However, the in vivo role of non-genomic estrogen signaling in bone growth and development is unknown. The description of G-protein-dependent estrogen signaling and membrane localization of estrogen-binding sites has led to the

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P Michael Conn, Jo Ann Janovick, Shaun P Brothers and Paul E Knollman

Misfolding of protein mutants in disease Often, mutant proteins lose function in cells. Loss of activity frequently results from misfolding but, until recently, it was believed to be solely explained by loss of protein function

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László Szidonya, Miklós Cserző and László Hunyady

Introduction The superfamily of the G-protein-coupled receptors (GPCRs) makes up the largest group of membrane receptors ( Fredriksson & Schioth 2005 ). They respond to a large variety of stimuli, including biogenic amines, peptides

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Hiroyuki Otani, Fumio Otsuka, Masaya Takeda, Tomoyuki Mukai, Tomohiro Terasaka, Tomoko Miyoshi, Kenichi Inagaki, Jiro Suzuki, Toshio Ogura, Mark A Lawson and Hirofumi Makino

. Bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-β (TGF-β or TGFB1 as listed in MGI Database) superfamily, were originally identified as the active components in bone extracts capable of inducing bone formation at

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Hong Ma, Jin Yuan, Jinyu Ma, Jie Ding, Weiwei Lin, Xinlei Wang, Mingliang Zhang, Yi Sun, Runze Wu, Chun Liu, Cheng Sun and Yunjuan Gu

free of such side effects are urgently needed to cure the increasing number of T2D patients. Bone morphogenetic protein 7 (BMP7), a member of the transforming growth factor-β (TGF-β) family, has been reported to induce the conversion of white adipose

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S Elis, J Dupont, I Couty, L Persani, M Govoroun, E Blesbois, F Batellier and P Monget

Introduction Recent evidence indicates that bone morphogenetic proteins (BMPs) are expressed in a cell-specific manner in the mammalian ovary, and they play key roles in the regulation of folliculogenesis, ovulation, and corpus

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Guoyue Yuan, Xia Chen, Qinyun Ma, Jie Qiao, Rongying Li, Xuesong Li, Shengxian Li, Jinfeng Tang, Libin Zhou, Huaidong Song and Mingdao Chen

and its plasma concentrations in rodents and human subjects ( Maeda et al. 2001 , Combs et al. 2002 ). C-reactive protein (CRP) is one of the most sensitive inflammatory markers. An association of CRP to the development of