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Gerard Karsenty

endocrine organ of major importance. Multiple studies have shown that bone, via an osteoblast-secreted hormone called osteocalcin, promotes β-cell proliferation, insulin secretion, and insulin sensitivity in muscle, liver, and white adipose tissue ( Lee et

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Mei-Fway Iu, Hiroshi Kaji, Hideaki Sowa, Junko Naito, Toshitsugu Sugimoto and Kazuo Chihara

resorption may be the secondary events following the decreased number and activity of osteoblasts. Actually, the effect of GC on bone formation seems to be more crucial in the pathogenesis of GIO ( Canalis 1996 ). Nevertheless, the mechanism of GC

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Nicholaos I Papachristou, Harry C Blair, Kyriakos E Kypreos and Dionysios J Papachristou

functionality ( Filou et al . 2016 ), suggesting that the understanding of HDL proteome and the factors affecting it, are crucial steps in successfully improving HDL functionality. Biogenesis and function of bone cells Osteoblast, the bone

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Muneaki Ishijima, Kunikazu Tsuji, Susan R Rittling, Teruhito Yamashita, Hisashi Kurosawa, David T Denhardt, Akira Nifuji, Yoichi Ezura and Masaki Noda

of mineralized tissues and is one of the abundant non-collagenous proteins in bone matrix produced by osteoblasts, osteoclasts, and probably osteocytes ( Rodan 1991 , Butler et al. 1996 , Denhardt & Noda 1998 ). This protein contains an

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Victoria E DeMambro, Masanobu Kawai, Thomas L Clemens, Keertik Fulzele, Jane A Maynard, Caralina Marín de Evsikova, Kenneth R Johnson, Ernesto Canalis, Wesley G Beamer, Clifford J Rosen and Leah Rae Donahue

deletion of the type I IGF receptor ( Igf1r ) in osteoblasts causes a profound reduction in trabecular bone volume and osteoblast function, and changes in mineralization lag time ( Zhang et al . 2002 ). Furthermore, engineered knockout and transgenic

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Saranyapin Potikanond, Pinyada Rattanachote, Hiranya Pintana, Panan Suntornsaratoon, Narattaphol Charoenphandhu, Nipon Chattipakorn and Siriporn Chattipakorn

cultured for 24 h in DMEM which was supplemented with 10% FBS as previously described ( Pramojanee et al . 2013 ). Cell proliferation and apoptosis assay was carried out by the following method: the osteoblasts isolated from all groups were plated in 96

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Ichiro Kaneko, Rimpi K Saini, Kristin P Griffin, G Kerr Whitfield, Mark R Haussler and Peter W Jurutka

) near or remote to each target gene ( Haussler et al . 2013 ). Fibroblast growth factor 23 (FGF23) is an osteoblast/osteocyte-elaborated, phosphaturic hormone that feedback represses CYP27B1 and induces CYP24A1 to limit the levels of active 1,25D

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Bronwen A J Evans, Melanie J Bull, Rebecca C Kench, Rebecca E Fox, Liam D Morgan, Amy E Stevenson, Evelien F Gevers, Mark J Perry and Timothy Wells

chronic infusion of leptin into the tibial marrow cavity of Sprague–Dawley (SD) and dw/dw rats. Our data suggest that while leptin may favour the differentiation of osteoblasts, hyperleptinaemia exerts only a minimal influence on the impaired trabecular

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Fan He, Xiaozhen Liu, Ke Xiong, Sijin Chen, Long Zhou, Wenguo Cui, Guoqing Pan, Zong-Ping Luo, Ming Pei and Yihong Gong

hematopoietic cells ( Hamilton & Campbell 1991 ). Bone structures undergo a continuous remodeling process of resorption and formation via osteoclasts and osteoblasts, which are responsible for destroying the old bone architecture and building a new one

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Christianne M A Reijnders, Nathalie Bravenboer, Annechien M Tromp, Marinus A Blankenstein and Paul Lips

.808). Ribosomal 28S RNA expression in tibiae Analysis of ribosomal 28S RNA in control tibiae using non-radioactive in situ hybridization exhibited cytoplasmatic expression within every cell type, including all osteocytes (Fig. 4A ), osteoblasts (Fig. 4