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John W Funder and Maria-Christina Zennaro

-receptor specificity-conferring mechanisms in epithelia, John Funder documents the context-dependent bivalent (agonist, antagonist) role of cortisol in MR, an unanticipated inverse agonist action of spironolactone on MR, and points to the sorts of studies that the next

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Charlotte Lawson, Jose M Vicencio, Derek M Yellon and Sean M Davidson

budding and shedding from the plasma membrane of cells and therefore may contain specific surface markers from the cell of origin. Exosomes (50–100 nm) on the other hand originate intracellularly through a sorting pathway involving intermediate organelles

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Sophie E Leney and Jeremy M Tavaré

localisation through a combination of slow exocytosis and rapid endocytosis. Additional studies in 3T3-L1 adipocytes have suggested that the slow recycling of GLUT4 is due to a dynamic sorting process that involves the continuous budding and fusion of GLUT4

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Patricia Vázquez, Isabel Roncero, Enrique Blázquez and Elvira Alvarez

Neurochemistry 67 1982 –1991. Ohno H , Stewart J, Fournier M-C, Bosshart H, Rhee I, Miyatake J, Saito T, Galluser A, Kirchhausen T & Bonifacino JS 1995 Interaction of tyrosine-based sorting signals with clathrin

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Susana I Sá and Bruno M Fonseca

enhanced by its ability to promote post-estrous refractoriness, ending the estrous behavior and inducing a sort of reset of the neuronal circuitry involved in the regulation of female sexual behavior ( Parsons et al . 1981 , Mani & Oyola 2012 ). In a

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Meng Guo, Yuna Li, Yan Wang, Zhenkun Li, Xiaohong Li, Peikun Zhao, Changlong Li, Jianyi Lv, Xin Liu, Xiaoyan Du and Zhenwen Chen

lentiviral vectors. The viral supernatants were collected by ultracentrifugation. After infection, C2C12 cells were isolated using an FACSCalibur cell sorter (BD Biosciences, USA). The homology between the mRNA coding regions of Eef1a1 and Eef1a2 is low

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K Eerola, S Virtanen, L Vähätalo, L Ailanen, M Cai, V Hruby, M Savontaus and E Savontaus

sorting sequences of pro-opiomelanocortin and the endogenous cleavage sites for appropriate intracellular processing. Enzymatic cleavage of the N-terminal POMC by protein convertases (PC) 1/3 and 2 produces γ 3 -MSH. The vector uses the vesicular

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Nan Li, James A Oakes, Karl-Heinz Storbeck, Vincent T Cunliffe and Nils P Krone

sorted into groups with either dark or light pigmentation ( Fig. 1C ). Subsequent genotyping revealed over 90% of VBA-negative larvae were cyp11a2 −/− mutants (Supplementary Table 2). VBA-positive larvae were either wild-type or cyp11a2

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Joost J F P Luiken, D Margriet Ouwens, Daphna D J Habets, Gerard C M van der Zon, Will A Coumans, Robert W Schwenk, Arend Bonen and Jan F C Glatz

bound to endosomal membranes, and is actively participating in the sorting of GLUT4 and CD36. Hence, PKC-ζ keeps the sorting machinery for both GLUT4 and CD36 in a pre-active state, so that an incoming insulin signal through PI3K and Akt/PKB, and

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J M Mellado-Gil and M Aguilar-Diosdado

1995 Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro. Transplantation Proccedings 27 3271 –3275. Stennicke HR & Salvesen GS 2000 Caspases