Search Results

You are looking at 71 - 80 of 249 items for :

  • "steatosis" x
Clear All
Free access

Jillian L Rourke, Shanmugam Muruganandan, Helen J Dranse, Nichole M McMullen and Christopher J Sinal

under the curve (AUC) for insulin was calculated using the Prism6 Software (La Jolla, CA, USA). Liver steatosis, adipocyte hypertrophy, and inflammation are common features of obesity, contributing to the development of glucose intolerance. Gpr1 WT

Restricted access

Chaoyi Zhang, Qianli Zhang, Zhihong Huang and Quan Jiang

). Adropin-knockout mice exhibit increased adiposity, fasting triglycerides and hepatic steatosis ( Ganesh Kumar et al. 2012 ). Moreover, intraperitoneal administration of adropin to hyperlipidemic rats for 10 days was extremely effective in decreasing the

Free access

Richard A Ehrhardt, Andreas Foskolos, Sarah L Giesy, Stephanie R Wesolowski, Christopher S Krumm, W Ronald Butler, Susan M Quirk, Matthew R Waldron and Yves R Boisclair

transition from LP to EL. Liver steatosis is a common feature of leptin-deficient rodents and was specifically attributed to reduced lipid oxidation by pair-feeding these animals to wild-type controls ( Cohen et al . 2002 , Prieur et al . 2008 ). Leptin

Restricted access

Akiko Mizokami, Satoru Mukai, Jing Gao, Tomoyo Kawakubo-Yasukochi, Takahito Otani, Hiroshi Takeuchi, Eijiro Jimi and Masato Hirata

intraperitoneal injection of GluOC, a more practical mode of administration, was as effective as was delivery with the osmotic pump. In addition to improving glucose handling, intermittent GluOC injections reversed hepatic steatosis induced by a high-fat diet and

Free access

Bel M Galmés-Pascual, Antonia Nadal-Casellas, Marco Bauza-Thorbrügge, Miquel Sbert-Roig, Francisco J García-Palmer, Ana M Proenza, Magdalena Gianotti and Isabel Lladó

role on the protection of liver from steatosis has been associated with a combined and balanced effect on lipid synthesis and secretion, and on mitochondrial biogenesis and function ( Sonoda et al. 2007 , Chambers et al. 2012 , Bellafante et al

Free access

João Paulo G Camporez, Mohamed Asrih, Dongyan Zhang, Mario Kahn, Varman T Samuel, Michael J Jurczak and François R Jornayvaz

biomarker of NAFLD ( Dushay et al . 2010 , Morris-Stiff & Feldstein 2010 ). In diet-induced obese mice, which have already increased levels of FGF21, suggesting a state of FGF21 resistance, chronic administration of FGF21 reverses hepatic steatosis and

Free access

Rachel Botchlett, Shih-Lung Woo, Mengyang Liu, Ya Pei, Xin Guo, Honggui Li and Chaodong Wu

various tissues causing steatosis and systemic insulin resistance. For example, increased FFAs impair the insulin signal in muscle ( Kim et al. 2002 ) and markedly stimulate hepatic gluconeogenesis ( Chu et al. 2002 ), which contribute to increased

Restricted access

Zhe-Zhen Liao, Xiao-Yan Qi, Ya-Di Wang, Jiao-Yang Li, Qian-Qian Gu, Can Hu, Yin Hu, Heng Sun, Li Ran, Jing Yang, Jiang-Hua Liu and Xin-Hua Xiao

) Mottillo EP Desjardins EM Crane JD Smith BK Green AE Ducommun S Henriksen TI Rebalka IA Razi A Sakamoto K , et al . 2016 Lack of adipocyte AMPK exacerbates insulin resistance and hepatic steatosis through brown and beige adipose

Free access

Carsten T Herz and Florian W Kiefer

. 2018 ). Whereas decreasing hypothalamic AMPK activity seems to confer some metabolic benefits, the loss of adipocyte AMPK exacerbates insulin resistance and hepatic steatosis through impaired brown and beige fat function ( Mottillo et al. 2016

Free access

Che-Pei Kung and Maureen E Murphy

underlie the role of p21/CDKN1A in the development of insulin resistance. p53 in the liver and skeletal muscle Hepatic steato­sis, or fatty liver, is one of the most common manifestations of obesity and type 2 diabetes ( Williams et al . 2013