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Kasper Faarkrog Høyer, Christoffer Laustsen, Steffen Ringgaard, Haiyun Qi, Christian Østergaard Mariager, Thomas Svava Nielsen, Ulrik Kræmer Sundekilde, Jonas T Treebak, Niels Jessen and Hans Stødkilde-Jørgensen

metabolic data and blood insulin, glucagon and free fatty acids following glucose challenge ( Kjærgaard et al. 2018 ). A generalized method for imaging pyruvate metabolism in the liver has tremendous promise for understanding human pathophysiology

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Karen R Kelly, Chin K Sung, Marcia J Abbott and Lorraine P Turcotte

Introduction It is well known that insulin affects skeletal muscle metabolism by increasing glucose uptake via GLUT-4 translocation from sarcolemmal vesicles to the plasma membrane (PM) and glycogen synthesis via activation of glycogen synthase

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Jillian L Rourke, Shanmugam Muruganandan, Helen J Dranse, Nichole M McMullen and Christopher J Sinal

acclimatization and analyzed using the Metabolism Software (Panlab Harvard Apparatus). Glucose homeostasis The glucose tolerance test (GTT) and insulin sensitivity test (IST) were carried out on conscious WT, HET, and KO mice at 6–7 weeks of age and following 7

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Malin Hedengran Faulds, Chunyan Zhao, Karin Dahlman-Wright and Jan-Åke Gustafsson

male patient with loss of ERα function, display impaired glucose metabolism, IR, and hyperinsulinemia ( Zirilli et al . 2008 ). In addition, the aromatase-deficient patients showed impaired liver functions, hepatic steatosis, and altered lipid profile

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Victoria Diedrich, Elena Haugg, Carola Dreier and Annika Herwig

potential acute regulatory signals for the expression of spontaneous daily torpor and again differentiate long-term seasonal adaptations of glucose metabolism from acute changes in glucose availability that challenge the hamsters’ energy balance on a daily

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Philip Newsholme, Vinicius Cruzat, Frank Arfuso and Kevin Keane

) ), traditional models of insulin exocytosis are based on an increase in the β-cell intracellular ATP:ADP ratio, following elevated glucose metabolism. Enhanced flux through the glycolytic pathway and tricarboxylic acid cycle (TCA) results in elevated

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K J Oldknow, V E MacRae and C Farquharson

, regulating glucose homoeostasis, carbohydrate, lipid and protein metabolism, and promoting cell division and growth through its mitogenic effects (reviewed in Wilcox (2005) ); thus, insulin regulates whole-body energy utilisation, mediating its downstream

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Giselle Adriana Abruzzese, Maria Florencia Heber, Silvana Rocio Ferreira, Leandro Martin Velez, Roxana Reynoso, Omar Pedro Pignataro and Alicia Beatriz Motta

tissues is unknown. The liver is involved in lipid synthesis, transportation and storage, as well as in glucose and insulin metabolism ( Paschos & Paletas 2009 ), all key factors in PCOS pathogenesis ( den Boer et al . 2004 , Paschos & Paletas 2009

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Cho-Rong Bae, Kazuya Hasegawa, Sayaka Akieda-Asai, Yurie Kawasaki, Kazuyo Senba, Youn-Soo Cha and Yukari Date

responses of gastrointestinal hormones to food intake, glucose metabolism, and insulin signaling in male Wistar rats fed SP or CP on a 3-h restricted feeding schedule. We also evaluated energy intake, body weight, energy expenditure, and the amount of food

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Ulrika Bergström, Charlotte Lindfors, Marie Svedberg, Jeanette E Johansen, Jenny Häggkvist, Martin Schalling, Rolf Wibom, Abram Katz and Ida A K Nilsson

in wt mice ( Fig. 3 ). The lower glucose uptake was observed in other areas of the brain, as well as in the liver ( Fig. 3 ). To assess whether hypometabolism also occurred under stress conditions, carbohydrate and energy metabolism were quantified in