Search Results

You are looking at 71 - 80 of 1,825 items for :

  • transcriptional activity x
Clear All
Free access

Cecilia Engdahl, Caroline Jochems, Jan-Åke Gustafsson, Paul T van der Saag, Hans Carlsten and Marie K Lagerquist

Introduction Oestrogens are of importance for many functions in the body including regulation of the female reproductive system, skeletal growth and bone metabolism, and the immune system. Oestrogens affect gene transcription in target cells via two

Free access

Patricia Joseph-Bravo, Lorraine Jaimes-Hoy and Jean-Louis Charli

sites for specific transcription factors (TFs) whose activity is modulated by various signals ( Lee et al . 1988 ; Fig. 3 A). Chromatin remodeling constitutes the first step in transcriptional regulation; recruitment of specific TF, coregulators, and

Free access

XingJia Wang, Chwan-Li Shen, Matthew T Dyson, Xianling Yin, Randolph B Schiffer, Paula Grammas and Douglas M Stocco

. The present study further suggests that the AA metabolites produced by epoxygenase activity regulate StAR gene expression at the level of transcription. This was supported by the results from luciferase assays of StAR promoter activities and RT

Free access

Qiongge Zhang, Chaoqun Wang, Yehua Tang, Qiangqiang Zhu, Yongcheng Li, Haiyan Chen, Yi Bao, Song Xue, Liangliang Sun, Wei Tang, Xiangfang Chen, Yongquan Shi, Lefeng Qu, Bin Lu and Jiaoyang Zheng

 < 0.01 compared with LV-shNon (unpaired t test). FoxO1 enhanced the transcriptional activity of the OPN promoter regulated by high glucose As mentioned earlier, FoxO1 plays a role in the expression of OPN in macrophages. FoxO1 is a

Free access

Sanda Raulic, Yudith Ramos-Valdes and Gabriel E DiMattia

activity was lost upon deletion of DNA sequence between −172 and +127 in all three cell lines presumably due to elimination of the physiological transcriptional start sites. Figure 4 Human STC2 gene basal and hormone-inducible promoter activity in human

Free access

Paul W Caton, Nanda K Nayuni, Julius Kieswich, Noorafza Q Khan, Muhammed M Yaqoob and Roger Corder

et al . 2009 ) potentially through an AMPK-mediated increase in the transcription of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the salvage pathway for NAD + , an essential co-factor for SIRT1 activity ( Landry et al

Free access

Liat Abovich Gilad, Tali Bresler, Julia Gnainsky, Patricia Smirnoff and Betty Schwartz

Introduction Estrogen receptor (ER) is a member of a superfamily of nuclear transcription factors. The cellular actions of estrogen are thought to be mediated through transcriptional regulation of target genes ( Halachmi et al

Free access

J Kwakkel, W M Wiersinga and A Boelen

’Neill 2004 ). Although no direct relationship between NFκB and AP-1 activation and Sp1 activity has been shown, it is known that posttranslational modifications such as phosphorylation are important regulatory mechanisms of Sp1 transcriptional activity

Free access

Kishor Devalaraja-Narashimha and Babu J Padanilam

, that may contribute to obesity ( Brockmann & Bevova 2002 , Almind & Kahn 2004 , Ishimori et al . 2004 ). The possible contribution of this high number of genes and multiple changes at individual loci suggest that transcriptional regulation

Restricted access

Bethania Mongi-Bragato, Ezequiel Grondona, Liliana del Valle Sosa, Natacha Zlocowski, Ana Clara Venier, Alicia Inés Torres, Alexandra Latini, Rodrigo Bainy Leal, Silvina Gutiérrez and Ana Lucía De Paul

suggest that there exists a limited time period of transcriptional activity by NF-κB over the course of tumour progression. The NF-κB canonical pathway activation classically involves phosphorylation and proteasomal-mediated degradation of the inhibitory