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Kai Wang and Jing Zheng

the β (PPP3CB) constitutes ∼20–30% ( Im & Rao 2004 ). Like PPP2, PPP3 also participates in many cellular functions (e.g. immune responses and cardiac hypertrophy), partially via directly dephosphorylating members of nuclear factor of activated T cell

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Muraly Puttabyatappa, Robert M Sargis and Vasantha Padmanabhan

are associated with the development of cardiovascular defects ( Gaillard 2015 ). In sheep models of maternal obesity, offspring manifest hyperinsulinemia with increased activation of AKT, ERK, and mTOR in cardiac tissues with cardiac hypertrophy

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Michele O Wilson, Bryony A McNeill, Graham K Barrell, Timothy C R Prickett and Eric A Espiner

.11.008 ) 19948188 10.1016/j.brainresrev.2009.11.008 Pemberton CJ Yandle TG Charles CJ Rademaker MT Aitken GD Espiner EA 1997 Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure

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Kathryn L Gatford, Miles J De Blasio, Claire T Roberts, Mark B Nottle, Karen L Kind, William H E J van Wettere, Robert J Smits and Julie A Owens

clenbuterol from day 4 after mating and throughout pregnancy, although neonatal cardiac hypertrophy was also reported in this species ( Maltin et al . 1990 , Downie et al . 2008 ). Limited studies in women with suspected impaired fetal growth have also

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Alison J Forhead, Juanita K Jellyman, Katherine Gillham, Janelle W Ward, Dominique Blache and Abigail L Fowden

cytoarchitecture and secretory activity . Quarterly Journal of Experimental Physiology 68 15 – 27 . Segar JL Scholz TD Bedell KA Smith OM Huss DJ Guillery EN 1997 Angiotensin AT 1 receptor blockade fails to attenuate pressure-overload cardiac

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M B Mazzucco, R Higa, E Capobianco, M Kurtz, A Jawerbaum and V White

Siggens L Giussani DA Cross CM Foo R Ozanne SE 2012 The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation . Endocrinology 153 5961 – 5971 . ( doi:10

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Hao Wu, Junduo Wu, Shengzhu Zhou, Wenlin Huang, Ying Li, Huan Zhang, Junnan Wang and Ye Jia

induced cardiac hypertrophy . Molecular and Cellular Biochemistry 417 191 – 203 . ( 27221738 10.1007/s11010-016-2729-7 Rodgers JT Lerin C Haas W Gygi SP Spiegelman BM Puigserver P 2005 Nutrient control

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Marina C Muñoz, Valeria Burghi, Johanna G Miquet, Jorge F Giani, Ricardo D Banegas, Jorge E Toblli, Yimin Fang, Feiya Wang, Andrzej Bartke and Fernando P Dominici

the ACE2/Ang-(1–7)/Mas axis is involved in GH-mediated hypertension. Given the well-demonstrated beneficial effect of Ang-(1–7) in terms of reversal of cardiac hypertrophy ( Grobe et al . 2007 , Giani et al . 2010 ) and renal damage ( Benter et al

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Yun Wang, Yue Zheng, Patsy M Nishina and Jürgen K Naggert

. Altered levels of leptin and its receptor have been described in patients with chronic heart failure ( Garg & Yusuf 1993 , Patterson & Adams 1996 ). Several studies have shown a correlation between hyperleptinemia and cardiac hypertrophy ( Buckingham et

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Aline Cordeiro, Luana Lopes Souza, Marcelo Einicker-Lamas and Carmen Cabanelas Pazos-Moura

adipose tissue of rats treated with triiodothyronine . European Journal of Biochemistry 26 553 – 559 . ( doi:10.1111/j.1432-1033.1972.tb01798.x ) Dillmann W 2010 Cardiac hypertrophy and thyroid hormone signaling . Heart Failure Reviews 15