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Kai Wang and Jing Zheng

the β (PPP3CB) constitutes ∼20–30% ( Im & Rao 2004 ). Like PPP2, PPP3 also participates in many cellular functions (e.g. immune responses and cardiac hypertrophy), partially via directly dephosphorylating members of nuclear factor of activated T cell

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Muraly Puttabyatappa, Robert M Sargis and Vasantha Padmanabhan

are associated with the development of cardiovascular defects ( Gaillard 2015 ). In sheep models of maternal obesity, offspring manifest hyperinsulinemia with increased activation of AKT, ERK, and mTOR in cardiac tissues with cardiac hypertrophy

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Michele O Wilson, Bryony A McNeill, Graham K Barrell, Timothy C R Prickett and Eric A Espiner

.11.008 ) 19948188 10.1016/j.brainresrev.2009.11.008 Pemberton CJ Yandle TG Charles CJ Rademaker MT Aitken GD Espiner EA 1997 Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure

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Marina C Muñoz, Valeria Burghi, Johanna G Miquet, Jorge F Giani, Ricardo D Banegas, Jorge E Toblli, Yimin Fang, Feiya Wang, Andrzej Bartke and Fernando P Dominici

the ACE2/Ang-(1–7)/Mas axis is involved in GH-mediated hypertension. Given the well-demonstrated beneficial effect of Ang-(1–7) in terms of reversal of cardiac hypertrophy ( Grobe et al . 2007 , Giani et al . 2010 ) and renal damage ( Benter et al

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Márta Szaszák, Hung-Dar Chen, Hao-Chia Chen, Albert Baukal, László Hunyady and Kevin J Catt

pathogenesis of renal diseases and several cardiovascular disorders, including hypertension, cardiac hypertrophy, and atherosclerosis, and has been implicated in the Marfan syndrome and cancer. In addition to its classical target tissues, local AngII formation

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Ji-Eun Kim, Seung Eun Song, Yong-Woon Kim, Jong-Yeon Kim, Sung-Chul Park, Yoon-Ki Park, Suk-Hwan Baek, In Kyu Lee and So-Young Park

.vetimm.2003.09.005 . Takimoto E Kass DA 2007 Role of oxidative stress in cardiac hypertrophy and remodeling . Hypertension 49 241 – 248 doi:10.1161/01.HYP.0000254415.31362.a7 . Tan KC Xu A Chow WS Lam MC Ai VH Tam SC Lam KS 2004

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M B Mazzucco, R Higa, E Capobianco, M Kurtz, A Jawerbaum and V White

Siggens L Giussani DA Cross CM Foo R Ozanne SE 2012 The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation . Endocrinology 153 5961 – 5971 . ( doi:10

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Alison J Forhead, Juanita K Jellyman, Katherine Gillham, Janelle W Ward, Dominique Blache and Abigail L Fowden

cytoarchitecture and secretory activity . Quarterly Journal of Experimental Physiology 68 15 – 27 . Segar JL Scholz TD Bedell KA Smith OM Huss DJ Guillery EN 1997 Angiotensin AT 1 receptor blockade fails to attenuate pressure-overload cardiac

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Peter J Fuller, Yizou Yao, Jun Yang and Morag J Young

.mce.2003.10.009 . Qin W Rudolph AE Bond BR Rocha R Blomme EAG Goeliner JJ Funder JW McMahon EG 2003 Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure . Circulation Research 93 69 – 76 . doi:10.1161/01.RES

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Kathryn L Gatford, Miles J De Blasio, Claire T Roberts, Mark B Nottle, Karen L Kind, William H E J van Wettere, Robert J Smits and Julie A Owens

clenbuterol from day 4 after mating and throughout pregnancy, although neonatal cardiac hypertrophy was also reported in this species ( Maltin et al . 1990 , Downie et al . 2008 ). Limited studies in women with suspected impaired fetal growth have also