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Gary J Remington, Celine Teo, Virginia Wilson, Araba Chintoh, Melanie Guenette, Zohra Ahsan, Adria Giacca and Margaret K Hahn

, resulting in increased glycolysis and glucose uptake, decreased liver lactate uptake and decreased use of lactate as a substrate for glucose production ( Radziuk et al . 1997 , Owen et al . 2000 , Otto et al . 2003 ). However, Met is also known to

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Thomas Laeger, Ralf Pöhland, Cornelia C Metges and Björn Kuhla

vivo could not be simply applied to the cell culture. GT1-7 cells were generated via tumourigenesis ( Mellon et al . 1990 ) and possess a approximately ten times higher glucose uptake and glycolysis rate compared with non-oncogenic cells ( Dang

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Kunihisa Hamano, Yuko Nakagawa, Yoshiaki Ohtsu, Longfei Li, Johan Medina, Yuji Tanaka, Katsuyoshi Masuda, Mitsuhisa Komatsu and Itaru Kojima

activation of the glucose-sensing receptor led to an increase in [ATP] c by facilitating glucose metabolism ( Nakagawa et al . 2014 ). Accordingly, artificial sweeteners increase [ATP] c even though they do not serve as substrates for glycolysis. We next

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Camila Martinez Calejman, Juan M Di Gruccio, María E Mercau, Esteban M Repetto, Francisco Astort, Rocío Sanchez, Matías Pandolfi, Gabriela Berg, Laura Schreier, Pablo Arias and Cora B Cymeryng

. Fructose generated by sucrose hydrolysis in the gut is mainly metabolized in the liver. As it bypasses key regulatory steps in glycolysis, most of the fructose ingested is promptly converted to fatty acids that are esterified into triglycerides, which are

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Sofianos Andrikopoulos, Barbara C Fam, Anita Holdsworth, Sherley Visinoni, Zheng Ruan, Maria Stathopoulos, Anne W Thorburn, Christos N Joannides, Michael Cancilla, Lois Balmer, Joseph Proietto and Grant Morahan

to glucose-6-phosphate by the rate-determining enzyme, glucokinase (GK). This results in an increased flux through glycolysis and the tricarboxylic acid cycle causing a rise in the ATP:ADP ratio. The elevated ATP:ADP ratio closes the cell surface ATP

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Saeed Alshahrani, Mohammed Mashari Almutairi, Shams Kursan, Eduardo Dias-Junior, Mohamed Mahmoud Almiahuob, Lydia Aguilar-Bryan and Mauricio Di Fulvio

: facilitated diffusion of glucose into β-cells, phosphorylation of the sugar and consumption via glycolysis, increased ATP/ADP ratio, closure of ATP-sensitive K + (K ATP )-channels, plasma membrane depolarization, increased Ca 2+ influx due to opening of

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Paula J Brunton, Katie M Sullivan, David Kerrigan, John A Russell, Jonathan R Seckl and Amanda J Drake

regulation of hepatic gluconeogenesis and glycolysis . Annual Review of Physiology 54 885 – 909 . ( doi:10.1146/annurev.ph.54.030192.004321 ) Seckl JR Holmes MC 2007 Mechanisms of disease: glucocorticoids, their placental metabolism and fetal

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Bishnu Adhikari, Prabhat Khanal and Mette Olaf Nielsen

glucagon. Glucagon increases hepatic glucose output through stimulation of gluconeogenesis, glycogenolysis and by inhibiting glycogenesis and glycolysis. Glucagon stimulates gluconeogenesis mainly through upregulation of the key enzymes; PEPCK , G6PC and

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Darryl L Hadsell, Walter Olea, Nicole Lawrence, Jessy George, Daniel Torres, Takahashi Kadowaki and Adrian V Lee

apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes and Development 15 1406 –1418. Hadsell DL , Alexeenko T, Klemintidis Y, Torres D & Lee AV

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Karen Oliva, Gillian Barker, Gregory E Rice, Mark J Bailey and Martha Lappas

oxidative stress. In support of our studies, 2D-DIGE also revealed that the antioxidant enzyme PRX2 was found to be down-regulated in PCOS omental fat ( Corton et al . 2008 ). Energy and lipid metabolism Lactate dehydrogenase (LDH) is involved in glycolysis