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Jay W Porter, Joe L Rowles III, Justin A Fletcher, Terese M Zidon, Nathan C Winn, Leighton T McCabe, Young-Min Park, James W Perfield II, John P Thyfault, R Scott Rector, Jaume Padilla and Victoria J Vieira-Potter

.05). Exercise improves adipose tissue insulin sensitivity in FGF21KO mice Based on HOMA-IR values, FGF21KO mice were significantly more insulin-resistant than WT controls ( Fig. 1A ) and EX had a tendency ( P  = 0.112) to improve HOMA-IR in both genotypes

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L Lundholm, G Bryzgalova, H Gao, N Portwood, S Fält, K D Berndt, A Dicker, D Galuska, J R Zierath, J-Å Gustafsson, S Efendic, K Dahlman-Wright and A Khan

risk of developing type 2 diabetes ( Louet et al . 2004 ), while treatment with 17β-estradiol (E 2 ) or conjugated equine estrogens improves insulin sensitivity and lowers blood glucose levels ( Espeland et al . 1998 , Crespo et al . 2002 , Saglam

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Zhengxiang Huang, Lili Huang, Chengjian Wang, Shanli Zhu, Xinzhou Qi, Yang Chen, Yanjun Zhang, Michael A Cowley, Johannes D Veldhuis and Chen Chen

type 2 diabetes (T2D). Restoration of physiological levels of insulin and GH in obesity is of particular importance to maintain healthy body composition and insulin sensitivity, as well as lipid and glucose metabolism. Sodium-glucose cotransporter 2

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Susan Kralisch, Johannes Klein, Ulrike Lossner, Matthias Bluher, Ralf Paschke, Michael Stumvoll and Mathias Fasshauer

contrast, the adipocytokine adiponectin is downregulated in states of impaired insulin sensitivity and appears as an endogenous insulin sensitizer ( Fasshauer & Paschke 2003 ). Most recently, by using a differential display method, visfatin was

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Haiyong Chen, Hui-Yao Lan, Dimitrios H Roukos and William C Cho

-103/-107 in either liver or fat impaired the insulin sensitivity, and silencing of miR-103/107 in adipocytes enhanced insulin signaling, decreased adipocyte size, and enhanced insulin-stimulated glucose uptake via upregulating Caveolin-1 , a critical

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Frank H Bloomfield

), experimental studies investigating insulin sensitivity in children and young adults, which report decreased insulin sensitivity in those born preterm compared with term-born controls ( Hofman et al . 2004 , Hovi et al . 2007 , Rotteveel et al . 2008

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Li Li, Xiaohua Li, Wenjun Zhou and Joseph L Messina

presented in A, B, and C. White gap in A, B, and C indicates grouping of lanes from different parts of the same gel. Acute psychological stress impairs glucose tolerance and insulin sensitivity We next tested whether acute psychological stress induced by IES

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Tomoaki Hayakawa, Tomomi Minemura, Toshiharu Onodera, Jihoon Shin, Yosuke Okuno, Atsunori Fukuhara, Michio Otsuki and Iichiro Shimomura

.e.m. Figure 4 Effect of adipocyte MR deletion on insulin sensitivity and glucose handling. Mice fed HFHSD from 5 weeks of age underwent insulin tolerance test (ITT) 14 weeks after HFHSD feeding (A, n  = 7 in the MR flox/flox group; n  = 8 in the AdipoMR

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B D Green, N Irwin, V A Gault, C J Bailey, F P M O’Harte and P R Flatt

weight, glucose tolerance, pancreatic β-cell function and insulin sensitivity were recorded. These measurements were repeated after a 9-day recovery period to evaluate the effects of alleviation of GLP-1 receptor antagonism. Comparative studies were

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Björn Åkerblom, Sebastian Barg, Gabriela Calounova, Dariush Mokhtari, Leif Jansson and Michael Welsh

mice was measured between 0845 and 0920 h and analyzed with the Freestyle Mini System. Insulin sensitivity test Wild-type and Shb−/− male mice were given an i.p. injection (1.6 U/kg body weight) of the insulin analog NovoRapid (Novo Nordisk, Bagsværd