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Masaki Nakano, Mika Ikegame, Junko Igarashi-Migitaka, Yusuke Maruyama, Nobuo Suzuki and Atsuhiko Hattori

is composed of three types of component cells, osteoclasts, osteoblasts and osteocytes, and an intercellular matrix consisting of type I collagen and hydroxyapatite. Osteocytes are the predominant cell type in bone tissue, accounting for more than 90

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Norihiko Kato, Keiichiro Kitahara, Susan R Rittling, Kazuhisa Nakashima, David T Denhardt, Hisashi Kurosawa, Yoichi Ezura and Masaki Noda

, which is expressed in both osteoblasts and osteoclasts in bone in response to cytokines and mechanical signals to modulate osteoblastic functions as well as osteoclastic functions ( Noda & Denhardt 2002 ). OPN inhibits mineral crystal growth both in

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Shoshana Yakar, Mary L Bouxsein, Ernesto Canalis, Hui Sun, Vaida Glatt, Caren Gundberg, Pinchas Cohen, David Hwang, Yves Boisclair, Derek LeRoith and Clifford J Rosen

primarily in the vascular system, dissociates, the binary complexes of IGFBP–IGFs are removed from the circulation and IGF-I reaches target tissues where it interacts with cell surface receptors. In the skeleton, IGF-I is important for osteoblast

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Jung-Min Koh, Young-Sun Lee, Chang-Hyun Byun, Eun-Ju Chang, Hyunsoo Kim, Yong Hee Kim, Hong-Hee Kim and Ghi Su Kim

been addressed. We therefore tested the effects of α-LA on osteoblast-lineage cells and osteoclasts, and observed a dissociation of receptor activator of nuclear factor κB (NF-κB) ligand (RANKL) expression and osteoclastogenesis. That is, α-LA markedly

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Dimitrios Agas, Guilherme Gusmão Silva, Fulvio Laus, Andrea Marchegiani, Melania Capitani, Cecilia Vullo, Giuseppe Catone, Giovanna Lacava, Antonio Concetti, Luigi Marchetti and Maria Giovanna Sabbieti

compartment as a partially autonomous environment strategic for evaluating the levels of cytokines that target bone ( Harsløf et al. 2013 ). Mesenchymal stem cells’ (MSCs) fate to osteoblasts is negatively influenced by pINF-γ Next, in BMSCs, we

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Guillaume Mabilleau, Aleksandra Mieczkowska, Nigel Irwin, Peter R Flatt and Daniel Chappard

remodeling necessitates a spatiotemporal coupling between osteoclasts, the bone-resorbing cells, and osteoblasts, the bone-forming cells. Bone remodeling is a complex process regulated by various stimuli that may affect osteoclast and osteoblast physiologies

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David E Maridas, Victoria E DeMambro, Phuong T Le, Kenichi Nagano, Roland Baron, Subburaman Mohan and Clifford J Rosen

et al . 2013 ). IGFBP-4, which is highly expressed in adipocytes and osteoblasts, is the smallest IGF-binding protein and contains a cleavage site for pregnancy-associated plasma protein A (PAPPA). It also circulates in relatively substantial amounts

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Wang Xiao, Fei Beibei, Shen Guangsi, Jiang Yu, Zhang Wen, Huang Xi and Xu Youjia

been reported ( Jia et al . 2012 , He et al . 2013 ) and reactive oxygen species (ROS) were involved in iron-induced osteopenia ( Li et al . 2012 ). ROS attenuate osteoblastogenesis, decrease osteoblast/osteocyte lifespan, and are required for

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J Jeyabalan, M Shah, B Viollet, J P Roux, P Chavassieux, M Korbonits and C Chenu

metformin, are osteogenic in vitro . They stimulate proliferation, differentiation and mineralisation of MC3T3-E1 osteoblastic cells ( Kanazawa et al . 2008 , 2009 , Jang et al . 2011 a , b , Mai et al . 2011 ), primary osteoblasts ( Shah et al

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Corine Martineau, Louise Martin-Falstrault, Louise Brissette and Robert Moreau

Introduction Bone tissue is constantly renewed in a process called remodeling. Remodeling relies on the activities of specialized cells, bone-forming osteoblasts, and bone-resorbing osteoclasts, to maintain bone mass ( Clarke 2008 ). The balance