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Vincent Ricchiuti, Nathalie Lapointe, Luminita Pojoga, Tham Yao, Loc Tran, Gordon H Williams and Gail K Adler

on CV pathophysiology, we determined the effects of liberal or high-sodium (HS) and low-sodium (LS) diets on aldosterone and ANGII pathways in the hearts of healthy rodents. We examined the cardiac protein levels of receptors for ANGII and aldosterone

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Takaharu Maruyama, Kenichi Tanaka, Jun Suzuki, Hiroyuki Miyoshi, Naomoto Harada, Takao Nakamura, Yasuhisa Miyamoto, Akio Kanatani and Yoshitaka Tamai

inhibited cAMP formation in a cell line expressing membrane progestin receptor (mPR) and that the response was sensitive to the pertussis toxin, suggesting that mPR is coupled to the Gi/o protein ( Zhu et al. 2003 a , b ). In addition, bile acid has been

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Brad G Hoffman and Steven J M Jones

binding sites ( Elnitski et al . 2006 , Wu et al . 2006 , Collas & Dahl 2008 , Massie & Mills 2008 ). For this purpose, cells are typically initially treated with a cross-linking agent, often formaldehyde, to covalently link DNA-binding proteins to

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Harn-Shen Chen, Tzu-En Wu, Chi-Chang Juan and Hong-Da Lin

Introduction Abnormalities of the cardiovascular systems are common in diabetic patients and the consequences are devastating ( Fein 1990 , Grossman & Messerli 1996 , Sowers et al . 2001 , Fang et al . 2004 ). Heat shock proteins play cardio

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S K Richards, L E Parton, I Leclerc, G A Rutter and R M Smith

b ), erythropoietin ( Fenjves et al. 2004 ) or a tumour necrosis factor (TNF) receptor fusion decoy ( Machen et al. 2004 ), is considered an exciting approach. Adenosine monophosphate-activated protein kinase (AMPK), an evolutionarily

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Susan Gray, Barbara S Stonestreet, Shanthie Thamotharan, Grazyna B Sadowska, Molly Daood, Jon Watchko and Sherin U Devaskar

). Although studies have examined the effects of corticosteroids on glucose transporters in post-natal and adult rodents, studies have not examined the impact of antenatal corticosteroids on fetal skeletal muscle glucose transporter protein concentrations

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Antonius Plagge, Gavin Kelsey and Emily L Germain-Lee

The stimulatory G-protein signalling cycle Heterotrimeric G-proteins that are composed of α, β and γ-subunits, mediate signal transduction from a large number of activated seven-transmembrane receptors to diverse intracellular effector

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A M Carter, M J Kingston, K K Han, D M Mazzuca, K Nygard and V K M Han

). They promote proliferation, differentiation, migration and aggregation, and inhibit apoptosis; all processes involved in development. The bioavailability and biologic actions of IGFs are regulated by a family of six high-affinity binding proteins (BP

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Maria Petropavlovskaia, Julia Makhlin, John Sampalis and Lawrence Rosenberg

proteins identified in rat, mouse, hamster, and humans and of a recently isolated human Reg4 protein, have not been well defined. These proteins expressed in various parts of the digestive system, have been associated with acute pancreatitis, inflammatory

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Johannes Klein, Sören Westphal, Daniel Kraus, Britta Meier, Nina Perwitz, Volker Ott, Mathias Fasshauer and H Harald Klein

′-AMP-activated protein kinase (AMPK) has been implicated in metformin action in hepatocytes ( Zhou et al. 2001 ). By contrast to liver and muscle, relatively little is known about direct metformin actions in adipocytes. In rat adipose tissue