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Carsten T Herz and Florian W Kiefer

. 2018 ). Whereas decreasing hypothalamic AMPK activity seems to confer some metabolic benefits, the loss of adipocyte AMPK exacerbates insulin resistance and hepatic steatosis through impaired brown and beige fat function ( Mottillo et al. 2016

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Edra London, Michelle Bloyd and Constantine A Stratakis

activity after HFD feeding and decreased hepatic steatosis, but unlike the RIIβKO mouse, RIIαKO mice did not have marked increases in oxygen consumption that could explain the observed DIO resistance. Instead, it appears that the low, but very specific

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Victor P Bilan, Eman M Salah, Sheldon Bastacky, Huw B Jones, Rachel M Mayers, Bradley Zinker, Simon M Poucher and Stevan P Tofovic

medial hypertrophy/sclerosis  Absent 10 10 – 10  Minimal – – 2** –  Mild – – 6** –  Moderate – – 1** – Heart  Microvesicular steatosis  Absent 10 5 5 9  Minimal – 3 2 1  Mild – 2 2 –  Myocarditis  Absent 6 3 3 –  Minimal 4 3 4 1*  Mild – 4 2 9* Liver

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Paolo Comeglio, Ilaria Cellai, Tommaso Mello, Sandra Filippi, Elena Maneschi, Francesca Corcetto, Chiara Corno, Erica Sarchielli, Annamaria Morelli, Elena Rapizzi, Daniele Bani, Daniele Guasti, Gabriella Barbara Vannelli, Andrea Galli, Luciano Adorini, Mario Maggi and Linda Vignozzi

reduced in HFD rabbits treated with INT-767, showing significantly decreased hepatic inflammation, steatosis, fibrosis and hypoxia. INT-767 effectively modulated the mRNA expression of several mediators of hepatic cholesterol uptake and metabolism and

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Laura B Lemke, Arlin B Rogers, Prashant R Nambiar and James G Fox

males ( n =12) and less frequently in mice less than 1 year of age exhibited moderate-to-severe centrilobular glycogen-associated hydropic degeneration superimposed over microvesicular and macrovesicular steatosis, and several had HCC. Steatosis was

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Isabelle Leclerc, Guy A Rutter, Gargi Meur and Nafeesa Noordeen

2010 Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice . Journal of Clinical Investigation 120 4316 – 4331 . doi:10.1172/JCI41624 . Bright RT

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Silva Sütt, Emmelie Cansby, Alexandra Paul, Manoj Amrutkar, Esther Nuñez-Durán, Nagaraj M Kulkarni, Marcus Ståhlman, Jan Borén, Jurga Laurencikiene, Brian W Howell, Sven Enerbäck and Margit Mahlapuu

hepatic lipid partitioning and progression of liver steatosis and NASH . FASEB Journal 29 1564 – 1576 . ( ) 10.1096/fj.14-264937 Amrutkar M Chursa U Kern M Nunez-Duran E Stahlman M Sutt S Boren J

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Chunyan Zhao and Karin Dahlman-Wright

needs to address that LXR activation is associated with stimulation of lipogenesis resulting in increased plasma TG levels and hepatic steatosis. Several in vivo studies have shown that rodents treated with T0901317 have massive TG accumulation in the

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Michael Mangubat, Kabirullah Lutfy, Martin L Lee, Laura Pulido, David Stout, Richard Davis, Chang-Sung Shin, Meghdi Shahbazian, Stephen Seasholtz, Amiya Sinha-Hikim, Indrani Sinha-Hikim, Laura E O'Dell, Alexei Lyzlov, Yanjun Liu and Theodore C Friedman

the HFD plus nicotine is actually a more beneficial combination than HFD alone. However, several recent animal studies have shown that cigarette smoking exacerbates hepatic steatosis triggered by HFD ( Liu et al . 2003 , Chen et al . 2007 a , Yuan

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Paula J Brunton, Katie M Sullivan, David Kerrigan, John A Russell, Jonathan R Seckl and Amanda J Drake

triglyceride concentrations were increased in PNS males, and although hepatic triglyceride levels were not altered by PNS in rats here fed a normal diet, we have previously shown that exposure to a high-fat diet drives the development of hepatic steatosis in