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Susan Kralisch, Anke Tönjes, Kerstin Krause, Judit Richter, Ulrike Lossner, Peter Kovacs, Thomas Ebert, Matthias Blüher, Michael Stumvoll and Mathias Fasshauer

. FGF21-mediated suppression of STAT5 is accompanied by decreases in the expression of its target genes including IGF1 ( Inagaki et al . 2008 ). Furthermore, FGF21 induces hepatic expression of IGF1 binding protein 1 and suppressor of cytokine signaling

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Christophe Breton

activates the expression of suppressors of cytokine signalling 3 (SOCS3) that in turn inhibits leptin-induced tyrosine phosphorylation of JAK2 and STAT3 activation (indicated in red). The direct cross talk between insulin and leptin signalling at the level

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M B Mazzucco, R Higa, E Capobianco, M Kurtz, A Jawerbaum and V White

.placenta.2009.01.004 ) Vila L Roglans N Alegret M Sanchez RM Vazquez-Carrera M Laguna JC 2008 Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the

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Christopher M Mulligan and Jacob E Friedman

suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance . Diabetes Care 32 2281 – 2287 . ( doi:10.2337/dbib9-0979 ) Ghanim H Sia CL Upadhyay M Korzeniewski K

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E Oliveira, C R Pinheiro, A P Santos-Silva, I H Trevenzoli, Y Abreu-Villaça, J F Nogueira Neto, A M Reis, M C F Passos, E G Moura and P C Lisboa

-desensitization between leptin and prolactin signaling pathways despite the induction of suppressor of cytokine signaling 3 and PTP-1B . Journal of Endocrinology 195 341 – 350 . Sala F Nistri A Criado M 2008 Nicotinic acetylcholine receptors of adrenal

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Rajat Kumar Das, Sarmistha Banerjee and Bernard H Shapiro

contradiction with the accompanying ∼90% decline in CYP2C11 mRNA and protein. However, the episodic GH/JAK2/STAT5B signal transduction pathway is negatively regulated by tyrosine phosphatases ( Frank 2001 , Waxman & O'Connor 2006 ) and suppressors of cytokine

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Júlio Cezar de Oliveira, Egberto Gaspar de Moura, Rosiane Aparecida Miranda, Ana Maria Praxedes de Moraes, Luiz Felipe Barella, Ellen Paula Santos da Conceição, Rodrigo Mello Gomes, Tatiane Aparecida Ribeiro, Ananda Malta, Isabela Peixoto Martins, Claudinéia Conationi da Silva Franco, Patrícia Cristina Lisboa and Paulo Cezar de Freitas Mathias

(JAK2), phosphorylated-JAK2 (pJAK2), the suppressor of cytokine signaling 3 (SOCS3), androgen receptor (AR) and glucocorticoid receptor (GR) proteins in hypothalamus homogenates obtained from 60- and 120-day-old rats ( n  = 6) were measured using

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Sara Yosefi, Gideon Hen, Charles I Rosenblum, David J Cerasale, Michaël Beaulieu, Francois Criscuolo and Miriam Friedman-Einat

Klingenspor M 2004 Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus , is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression . Endocrinology 145 1185 – 1193 doi:10.1210/en

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Simon J Dunmore and James E P Brown

gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic β-cells . Diabetes 54 3410 – 3417 . ( doi:10.2337/diabetes.54.12.3410 ) Leahy JL Hirsch IB Peterson KA Schneider D 2010 Targeting β-cell function

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Johanna G Miquet, Lorena González, Marina N Matos, Christina E Hansen, Audreen Louis, Andrzej Bartke, Daniel Turyn and Ana I Sotelo

family of suppressors of cytokine-signaling (SOCS) proteins, which is involved in targeting receptor complexes for internalization and signal termination and was also reported to compete with STAT5b for binding sites in GHR ( Ram & Waxman 2000 , Landsman