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Christophe Breton

activates the expression of suppressors of cytokine signalling 3 (SOCS3) that in turn inhibits leptin-induced tyrosine phosphorylation of JAK2 and STAT3 activation (indicated in red). The direct cross talk between insulin and leptin signalling at the level

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Misuzu Yamashita, Fumio Otsuka, Tomoyuki Mukai, Hiroyuki Otani, Kenichi Inagaki, Tomoko Miyoshi, Junko Goto, Masahiro Yamamura and Hirofumi Makino

osteogenetic process. There has been recent evidence indicating that the effects of TNF-α are primarily associated with activation of MAPK signaling, which subsequently increases the activation of stress-related proteins such as NF-κB and suppressor of cytokine

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Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues and Lucila L K Elias

Stereotaxic Coordinates . San Diego, CA, USA : Academic Press . Peiser C McGregor GP Lang RE 2000 Leptin receptor expression and suppressor of cytokine signaling transcript levels in high-fat-fed rats . Life Sciences 67 . ( https://doi.org/10

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Lisa Rice, Charlotte E Waters, Jennifer Eccles, Helen Garside, Paula Sommer, Paul Kay, Fiona H Blackhall, Leo Zeef, Brian Telfer, Ian Stratford, Rob Clarke, Dave Singh, Adam Stevens, Anne White and David W Ray

  EMR1 2015 207111_at −2.0 0.185 EGF-like module containing, mucin-like, hormone receptor-like 1   SOCS3 9021 227697_at −1.9 0.198 Suppressor of cytokine signalling 3   LRP12 29 967 220254_at −1.9 0.143 Low density lipoprotein-related protein 12   RGS17

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Júlio Cezar de Oliveira, Egberto Gaspar de Moura, Rosiane Aparecida Miranda, Ana Maria Praxedes de Moraes, Luiz Felipe Barella, Ellen Paula Santos da Conceição, Rodrigo Mello Gomes, Tatiane Aparecida Ribeiro, Ananda Malta, Isabela Peixoto Martins, Claudinéia Conationi da Silva Franco, Patrícia Cristina Lisboa and Paulo Cezar de Freitas Mathias

(JAK2), phosphorylated-JAK2 (pJAK2), the suppressor of cytokine signaling 3 (SOCS3), androgen receptor (AR) and glucocorticoid receptor (GR) proteins in hypothalamus homogenates obtained from 60- and 120-day-old rats ( n  = 6) were measured using

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Lorena González, Johanna G Miquet, Pablo E Irene, M Eugenia Díaz, Soledad P Rossi, Ana I Sotelo, Mónica B Frungieri, Cristal M Hill, Andrzej Bartke and Daniel Turyn

.mrrev.2009.01.001 ) Wu WY Kim H Zhang CL Meng XL Wu ZS 2014 Loss of suppressors of cytokine signaling 3 promotes aggressiveness in hepatocellular carcinoma . Journal of Investigative Surgery 27 197 – 204 . ( doi:10

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Mohan Singh, Parvesh Chaudhry and Eric Asselin

C Boeuf H 2000 Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) -dependent embryonic stem cell survival . FASEB Journal 14 1577 – 1584 doi:10.1096/fj.14.11.1577 . Ernst M Inglese M Waring P

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Susan Kralisch, Anke Tönjes, Kerstin Krause, Judit Richter, Ulrike Lossner, Peter Kovacs, Thomas Ebert, Matthias Blüher, Michael Stumvoll and Mathias Fasshauer

. FGF21-mediated suppression of STAT5 is accompanied by decreases in the expression of its target genes including IGF1 ( Inagaki et al . 2008 ). Furthermore, FGF21 induces hepatic expression of IGF1 binding protein 1 and suppressor of cytokine signaling

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Barbara C Fam, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto and Sofianos Andrikopoulos

neuropeptide Y ( Npy ) and agouti related peptide ( Agrp ) and in the appetite-suppressing melanocortin pathway ( Huang et al . 2003 a , b ) were the predominant contributors, whereas other authors showed changes only in the suppressor of cytokine signalling 3

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Richard R Almon, Debra C DuBois, William Lai, Bai Xue, Jing Nie and William J Jusko

inhibit inflammatory signaling. SOCS2, which is a member of a family of suppressor of cytokine signaling proteins, is more highly expressed in the livers of WKY animals (Supplementary Table 2). SOCS2 interacts with another negative regulator of cytokine