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Guillaume Mabilleau, Benoit Gobron, Aleksandra Mieczkowska, Rodolphe Perrot and Daniel Chappard

-proteins) as well as in vitro collagen maturity and extent of osteoclast formation and resorption in vitro were analysed with the non-parametrical Kruskal–Wallis test. Due to the adaptive nature of bone, bone strength, bone microarchitecture and bone

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Madhusmita Misra and Anne Klibanski

biochemical markers of bone turnover and the patterns are different in AN as well. Adult women with AN have a decrease in markers of bone formation ( Grinspoon et al . 1996 , Hotta et al . 1998 ) and an increase in markers of bone resorption ( Grinspoon et

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Donlaporn Kittivanichkul, Narattaphol Charoenphandhu, Phisit Khemawoot and Suchinda Malaivijitnond

soy isoflavones . American Journal of Clinical Nutrition 68 1333S - 1346S . Sims NA Martin TJ 2014 Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit . BoneKEy Reports

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M J Devlin, C Grasemann, A M Cloutier, L Louis, C Alm, M R Palmert and M L Bouxsein

), and serum IGF1 by RIA (ALPCO) as described previously ( Bouxsein et al . 2002 ). Serum bone formation and resorption markers, type 1 procollagen N-terminal (P1NP) and collagen type 1 cross-linked C-telopeptide (CTX), were measured by ELISA

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Mone Zaidi, Maria I New, Harry C Blair, Alberta Zallone, Ramkumarie Baliram, Terry F Davies, Christopher Cardozo, James Iqbal, Li Sun, Clifford J Rosen and Tony Yuen

novel FSH-blocking agent as a means of uncoupling bone formation and bone resorption to a therapeutic advantage in people. An interesting alternative strategy, for which a proof-of-principle study is available, is the use of an FSHβ vaccine. It has been

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Viji Vijayan and Sarika Gupta

remodeling and many physiological functions in the body ( Schaffler & Kennedy 2012 , Dallas et al . 2013 ). For example, FGF23 produced by osteocytes regulate serum phosphate level while sclerostin and DKK1 regulate bone formation ( Bonewald & Johnson 2008

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K J Oldknow, V E MacRae and C Farquharson

formation and resorption or BMD in humans ( Ljunggren et al . 2012 ). In contrast, GLUT receptors have recently been reported to be expressed in bone. To date, the GLUT family consists of 14 members subclassified into three groups, according to sequence

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Therese Standal, Rachelle W Johnson, Narelle E McGregor, Ingrid J Poulton, Patricia W M Ho, T John Martin and Natalie A Sims

for osteoporosis capable of inducing bone formation (reviewed in Hodsman et al . (2005) and Khosla et al . (2008) ). However, the mechanisms by which intermittent PTH increases bone mass remain unclear, and identifying downstream targets of this

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Aran Son, Namju Kang, Sue Young Oh, Ki Woo Kim, Shmuel Muallem, Yu-Mi Yang and Dong Min Shin

Introduction Bone is a dynamic organ. It is constantly renewing through a bone remodeling process, mediated by osteoblastic bone formation and osteoclastic bone resorption. In numerous bone diseases, an imbalance in this process can be found

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Corine Martineau, Louise Martin-Falstrault, Louise Brissette and Robert Moreau

between bone formation and resorption involves the regulation of bone cell activities by several endocrine and paracrine axes including steroid hormones ( Frenkel et al . 2010 ), adrenocorticotropic hormone (ACTH; Isales et al . 2010 ), and cytokines