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Juliana Gastão Franco, Egberto Gaspar de Moura, Josely Correa Koury, Paula Affonso Trotta, Aline Cordeiro, Luana Lopes Souza, Norma Aparecida dos Santos Almeida, Natália da Silva Lima, Carmen Cabanelas Pazos-Moura, Patrícia Cristina Lisboa and Magna Cottini Fonseca Passos

, offspring of dams fed a low-protein diet during lactation had higher levels of sirtuin 1 (SIRT1) at 12 weeks of age that may regulate the aging process ( Chen et al . 2009 a ). Protein restriction in lactation has been associated with nephroprotective

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Emily Panagiotidou, Sophia Zerva, Dimitra J Mitsiou, Michael N Alexis and Efthymia Kitraki

during pregnancy and lactation. In total, 37 offspring were born in the BPA group (14 males and 23 females) and 48 offspring (22 males and 26 females) in the control group. Litters were culled to ten pups. Anogenital distances were measured at postnatal

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Patrycja A Jazwiec and Deborah M Sloboda

developing gonads appear to be similarly vulnerable to early life events and thus are likely to contribute to transgenerational disease risk. It is therefore plausible that since the gametes that will eventually give rise to grand-offspring form during

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Bettina A Ikenasio-Thorpe, Bernhard H Breier, Mark H Vickers and Mhoyra Fraser

shown alterations in NPY neurons in weanling and adult offspring of gestational diabetic rat dams, and in weanling offspring of perinatal low-protein fed rat dams ( Plagemann et al. 1999 , 2000 ). Recent research in fetal mice of protein

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E Oliveira, C R Pinheiro, A P Santos-Silva, I H Trevenzoli, Y Abreu-Villaça, J F Nogueira Neto, A M Reis, M C F Passos, E G Moura and P C Lisboa

al . 1997 ). Nicotine is transferred through maternal milk and causes tachycardia in the offspring due to higher adrenergic activity. Cotinine, the main metabolite of nicotine, can be measured in blood, urine, saliva, and milk ( Luck & Nau 1987

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Lin-guo Pei, Qi Zhang, Chao Yuan, Min Liu, Yun-fei Zou, Feng Lv, Da-ji Luo, Shan Zhong and Hui Wang

offspring rats, we aimed to confirm the presence of testicular development toxicity and explore its intrauterine programming mechanism by PCE. Moreover, by combining a chronic stress model in vivo and cell experiment in vitro , we clarified a

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Antonio Gonzalez-Bulnes, Susana Astiz, Cristina Ovilo, Clemente J Lopez-Bote, Raul Sanchez-Sanchez, Maria L Perez-Solana, Laura Torres-Rovira, Miriam Ayuso and Jorge Gonzalez

assessment of offspring development was carried out during both the prenatal (from day 50 of pregnancy to delivery) and the early-postnatal period (from birth to weaning at 28 days of age). At weaning, piglets were killed for evaluation of possible

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Clare M Reynolds and Mark H Vickers

reproductive disorders in offspring during adulthood. This relationship is preferentially termed ‘developmental programming’ or the ‘Developmental Origins of Adult Health and Disease’ (DOHaD). Original observations by Professor David Barker highlighted the

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Christopher M Mulligan and Jacob E Friedman

offspring microbiota. Galley and coworkers ( Galley et al . 2014 ) found that toddlers born to mothers with obesity had significantly elevated levels of Oscillibacter , Parabacteroides and an unclassified Bacteroidales genus and reduced levels of

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Laura B Lemke, Arlin B Rogers, Prashant R Nambiar and James G Fox

and 20 female offspring. The present study describes the clinicopathologic features of T2D in these SW offspring as well as the prevalence and characterization of this disease in the SW breeding colony where the disease was first recognized. Materials