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In vivo models of gestational and type 2 diabetes mellitus characterized by endocrine pancreas cell impairments

Sandra K Szlapinski

Sandra K Szlapinski London, Ontario, Canada

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David J Hill

David J Hill Diabetes, Endocrinology and Metabolism, Lawson Health Research Institute, London, Ontario, Canada
Physiology and Pharmacology, Western University, London, Ontario, Canada

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part, by increasing pancreatic BCM ( Beamish et al. 2017 a ). This pancreatic adaptation is driven predominantly by increased beta-cell replication in early pregnancy in rodent models, which is initiated by the rise in levels of the hormones

Article Type:: Review Article

Collections:: Insulin resistance and type 2 diabetes mellitus

DOI:: https://doi.org/10.1530/JOE-23-0317

Volume/Issue:: Volume 260: Issue 3

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In vivo techniques for assessment of insulin sensitivity and glucose metabolism

Margaret K Hahn

Margaret K Hahn Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada

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Adria Giacca

Adria Giacca Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Sandra Pereira

Sandra Pereira Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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. ( https://doi.org/10.1016/j.vascn.2007.12.002 ) Geisler CE Hepler C Higgins MR & Renquist BJ 2016 Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice . Nutrition and Metabolism 13 62 . ( https